|Prof. TANG Fuchou from Boidynamic Optical Imaging Center, Peking University visited Institute of Hydrobiology, Chinese Academy of Sciences (IHB) on Nov. 16, 2016. |
Prof. TANG Fuchou from Boidynamic Optical Imaging Center, Peking University visited Institute of Hydrobiology, Chinese Academy of Sciences (IHB) on Nov. 16, 2016. During his visit, Prof. Tang gave a lecture on the "Single-cell functional genomic studies of the human early embryo development".
Human primordial germ cell generates from early stage of early embryos. The primordial germ cells are the common origins of spermatozoa and oocytes and thus represent the ancestors of the germline. The genetic material is passed on to the offspring. Therefore, studies on human early embryos and development of primordial germ cell are essential to understand the recurrent abortion, embryo damage, infertility or other reproduction diseases.
Prof. Tang and his team developed the single cell RNA-Seqs, single-cell reduced-representation bisulfite sequencing and single-cell triple omics technology, and overcame the limitations to get large amount of human early embryos cells. Using these methods, they dissected the gene regulation network and DNA methylation landscape in mammalian pluripotent stem cells and early embryonic cells at single cell and single base levels, and provided a reference system of the epigenetic regulation of gene expression network at single cell level. Prof. Tang introduced their important achievements on origin of hematopoietic blood stem cells based on single cell omics analysis.
Prof. Tang is principle investigator at Boidynamic Optical Imaging Center, Peking University. His lab mainly focuses on the single cell functional genomics of early embryo development, and supported by the National Science Fund for Distinguished Young Scholars of China. Two researches of his lab were awarded the Top 10 China’s Scientific Advances in 2014 and 2015, respectively.