Center for Fish Biology and Fishery Biotechnology

Research Group of Fish Comparative Immunology and Healthy Aquaculture



PI: Prof. CHANG Mingxian, PhD 

Chief Members: Professor: LI Aihua; Assistant Professor: Dr. ZHANG Jie; Experimentalist: ZHANG Qianqian; Postdoctoral student: WU Xiaoman  

Contact Us:  

Tel: +86-27-68780760 


General Introduction: 

Research Group of Fish Comparative Immunology and Healthy Aquaculture has broad interest in fish immunology, molecular mechanisms of host-pathogen interactions, innate immune responses against pathogen infection, the mechanisms of pathogen clearance by innate immune receptors, the occurrence and development mechanisms of aquatic economic animal diseases.  

Current Research Interests:  

* Molecular mechanisms of innate immune recognition and signal transduction 

* Functional comparisons of innate immune signaling pathways in vertebrates 

* Immune-evading mechanisms of pathogens 

* The effects of interaction among metabolism, immunity and pathogen on the occurrence of aquatic economic animal diseases 


Recent publications: 

1.   Yang YY, Zheng SY, Fang H, Wu XM, Zhang J, Chang MX*. Immunoprotective Effects of Two Histone H2A Variants in the Grass Carp Against Flavobacterium columnare Infection. Frontiers in Immunology. 2022, 13: 939464. 

2.   Fang H, Yang YY, Wu XM, Zheng SY, Song YJ, Zhang J, Chang MX*. Effects and Molecular Regulation Mechanisms of Salinity Stress on the Health and Disease Resistance of Grass Carp. Frontiers in Immunology. 2022, 13:917497. 

3.  Zhang J, Man Wu X, Fang Q, Bi YH, Nie P, Chang MX*. Grass Carp Reovirus Nonstructural Proteins Avoid Host Antiviral Immune Response by Targeting the RLR Signaling Pathway. Journal of Immunology. 2022, 208(3):707-719.  

4.  Xiong F, Cao L, Xiong J, Wu YF, Huang WS, Chang MX*. Time-resolved and multi-tissue RNAseq provides new insights on the immune responses of European eels following infection with Aeromonas hydrophila. Water Biology and Security. 2022,1: 100003. 

5.  Hao Sun, Huina Zheng, Yiwei Jiang, Jinchang Liang, Baolin Liao, Ruixuan Wang, Aihua Li*, Baohua Xiao*. Elevated temperature alters bacterial community composition and metabolism in seawaters of coral reef ecosystem: An evidence of laboratory experiment with Acropora digitifera bleaching. Ecological Indicators. 2022: 139, 108886. 

6.  Lin, Yaoyao, Jicheng Yang, Zhenbing Wu, Qianqian Zhang, Shuyi Wang, Jingwen Hao, Lijian Ouyang*, Aihua Li*. Establishment of Epidemiological Resistance Cut-Off Values of Aquatic Aeromonas to Eight Antimicrobial Agents. Microorganisms, 2022, 10: 776. 

7.  Hao Sun, Huina Zheng, Baolin Liao, Bogui Chen, Aihua Li*, Baohua Xiao*. Algiphilus acroporae sp. nov. and Coraliihabitans acroporae gen. nov. sp. nov., isolated from scleractinian coral Acropora digitifera. International Journal of Systematic and Evolutionary Microbiology. 2022;72(4). doi: 10.1099/ijsem.0.005321. 

8.  Hao Sun, Huina Zheng, Xiaolei Wang, Yiwei Jiang, Baolin Liao, Aihua Li* and Baohua Xiao*. Flavobacterium coralii sp. nov., a marine bacterium isolated from coral culture seawater. International Journal of Systematic and Evolutionary Microbiology. 2022;72(1). doi: 10.1099/ijsem.0.005201. 

9.  Cao L, Yan D, Xiao J, Feng H, Chang MX*. The Zebrafish Antiapoptotic Protein BIRC2 Promotes Edwardsiella piscicida Infection by Inhibiting Caspases and Accumulating p53 in a p53 Transcription-Dependent and -Independent Manner. Frontiers in Immunology. 2021, 12:781680. 

10. Wu XM, Fang H, Zhang J, Bi YH, Chang MX*. Histone H2A Nuclear/Cytoplasmic Trafficking Is Essential for Negative Regulation of Antiviral Immune Response and Lysosomal Degradation of TBK1 and IRF3. Frontiers in Immunology. 2021, 12:771277. 

11. Qi ZT, Yan D, Cao L, Xu Y, Chang MX*. Zebrafish BID Exerts an Antibacterial Role by Negatively Regulating p53, but in a Caspase-8-Independent Manner. Frontiers in Immunology. 2021, 12:707426. 

12. Wu XM, Xiong F, Fang H, Zhang J, Chang MX*. Crosstalks between NOD1 and Histone H2A Contribute to Host Defense against Streptococcus agalactiae Infection in Zebrafish. Antibiotics (Basel). 2021, 10(7):861. 

13. Li PW, Chang MX*. Roles of PRR-Mediated Signaling Pathways in the Regulation of Oxidative Stress and Inflammatory Diseases. International Journal of Molecular Sciences. 2021, 22(14):7688. 

14. Chang MX*. The negative regulation of retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) signaling pathway in fish. Developmental and Comparative Immunology. 2021, 119:104038. 

15. Xiong F, Cao L, Wu XM, Chang MX*. The function of zebrafish gpbar1 in antiviral response and lipid metabolism. Developmental and Comparative Immunology. 2021, 116:103955. 

16. Zhenbing Wu, Qianqian Zhang, Tanglin Zhang, Jiwang Chen, Shuyi Wang, Jingwen Hao, Yaoyao Lin, Aihua Li*. Association of the microbiota dysbiosis in the hepatopancreas of farmed crayfish (Procambarus clarkii) with disease outbreaks. Aquaculture, 2021, 536: 

17. Qianqian Zhang, Yaoyao Lin, Tanglin Zhang, Yafeng Wu, Ping Fang, Shuyi Wang, Zhenbin Wu, Jingwen Hao, Aihua Li*. Etiological characteristics of “tail blister disease” of Australian redclaw crayfish (Cherax quadricarinatus). Journal of Invertebrate Pathology, 2021,184: 

18. Chang MX*. Xiong F. Astaxanthin and its Effects in Inflammatory Responses and Inflammation-Associated Diseases: Recent Advances and Future Directions. Molecules. 2020, 25(22):5342.  

19. Zhang J, Wu XM, Hu YW, Chang MX*. A Novel Transcript Isoform of TBK1 Negatively Regulates Type I IFN Production by Promoting Proteasomal Degradation of TBK1 and Lysosomal Degradation of IRF3. Frontiers in Immunology. 2020, 11:580864.  

20. Zhang Qian-Qian, Jian Sheng-Long, Li Ke-Mao, Wu Zhen-Bing, Guan Hong-Tao, Hao Jin-Wen, Wang Shu-YiLin Yao-Yao, Wang Guo-Jie*, LI Al-Hua*. Community structure of bacterioplankton and its relationship with environmental factors in the upper reaches of the Heihe River in Qinghai Plateau. Environmental Microbiology. 2020. doi: 10.1111/1462‐2920.15358. 

21. Zhenbing Wu, Shuyi Wang, Qianqian Zhang, Jinyong Zhang, Aihua Li*. Assessing the intestinal bacterial community of farmed Nile tilapia (Oreochromis niloticus) by high-throughput absolute abundance quantification. Aquaculture. 2020, 529:735688. 

22. Chang MX*, Xiong F, Wu XM, Hu YW. The expanding and function of NLRC3 or NLRC3-like in teleost fish: Recent advances and novel insights. Developmental and Comparative Immunology. 2021, 114:103859. 

23. Fang H, Wu XM, Hu YW, Song YJ, Zhang J, Chang MX*. NLRC3-like 1 inhibits NOD1-RIPK2 pathway via targeting RIPK2. Developmental and Comparative Immunology. 2020, 112:103769. 

24. Xiong F, Xiong J, Wu YF, Cao L, Huang WS, Chang MX*. Time-resolved RNA-seq provided a new understanding of intestinal immune response of European eel (Anguilla anguilla) following infection with Aeromonas hydrophila. Fish & Shellfish Immunology. 2020, 105:297-309. 

25. Wu XM, Zhang J, Li PW, Hu YW, Cao L, Ouyang S, Bi YH, Nie P, Chang MX*. NOD1 Promotes Antiviral Signaling by Binding Viral RNA and Regulating the Interaction of MDA5 and MAVS. Journal of Immunology. 2020, 204(8):2216-2231. 

26. Wu XM, Cao L, Hu YW, Chang MX*. Transcriptomic characterization of adult zebrafish infected with Streptococcus agalactiae. Fish & Shellfish Immunology. 2019, 94:355-372. 

27. Wu XM, Cao L, Nie P, Chang MX*. Histone H2A cooperates with RIP2 to induce the expression of antibacterial genes and MHC related genes. Developmental and Comparative Immunology. 2019, 101:103455.  

28. Cao L, Wu XM, Nie P, Chang MX*. The negative regulation of piscine CD44c in viral and bacterial infection. Developmental and Comparative Immunology. 2019, 96:135-143. 

29. Zhang J, Guo H, Zhang FX, Chen QX, Chang MX*, Fang Q*. NS38 is required for aquareovirus replication via interaction with viral core proteins and host eIF3A. Virology. 2019, 529:216-225. 

30. Wu XM, Chen WQ, Hu YW, Cao L, Nie P, Chang MX*. RIP2 Is a Critical Regulator for NLRs Signaling and MHC Antigen Presentation but Not for MAPK and PI3K/Akt Pathways. Frontiers in Immunology. 2018, 9:726.  

31. Cao L, Wu XM, Hu YW, Xue NN, Nie P, Chang MX*. The discrepancy function of NLRC5 isoforms in antiviral and antibacterial immune responses. Developmental and Comparative Immunology. 2018, 84:153-163. 

32. Hu YW, Zhang J, Wu XM, Cao L, Nie P, Chang MX*. TANK-Binding Kinase 1 (TBK1) Isoforms Negatively Regulate Type I Interferon Induction by Inhibiting TBK1-IRF3 Interaction and IRF3 Phosphorylation. Frontiers in Immunology. 2018, 9:84. 

33. Chang MX*, Zhang J. Alternative Pre-mRNA Splicing in Mammals and Teleost Fish: A Effective Strategy for the Regulation of Immune Responses Against Pathogen Infection. International Journal of Molecular Sciences. 2017, 18(7):1530. 

34. Hu YW, Wu XM, Ren SS, Cao L, Nie P, Chang MX*. NOD1 deficiency impairs CD44a/Lck as well as PI3K/Akt pathway. Scientific Reports. 2017, 7(1):2979.  

35. Wu XM, Hu YW, Xue NN, Ren SS, Chen SN, Nie P, Chang MX*. Role of zebrafish NLRC5 in antiviral response and transcriptional regulation of MHC related genes. Developmental and Comparative Immunology. 2017, 68:58-68.