Center for Fish Biology and Fishery Biotechnology

Research Group of Fish Developmental Genetics and Cell Engineering


PI: Prof. GUI Jianfang (CAS member) 

Chief members: ZHOU Li (Pro./Dr.), WANG Zhongwei (Pro./Dr.), TONG Jingou (Pro./Dr.), WANG Yang (Research associate), LI Xiyin (Research associate), LI Zhi (senior experimentalist), ZHANG Xiaojuan (Research Assistant)

Contact Us: 

Tel: 86-27-68780707 


General Introduction: 

Researches in this group are concentrated on three aspects. The first is attempting to reveal genetic basis of important economic traits in fish, focusing on gametogenesis and gynogenesis, sex determination and differentiation, immunity and disease resistance, and goldfish morphological diversity, and to develop biotechnologies of sex control and key gene editing-based breeding. The second is to integrate and reshape the genomes of polyploid fish, to reveal the genetic mechanisms on economic trait improvement in aquaculture fish caused by genome or sub-genome integration, and thereby to develop new biotechnologies of polyploidy and mono-sex breeding. The third is to create germplasm with excellent economic traits, to breed novel varieties of aquatic animals via genome wide selection, genome integration and reconstruction, gene edit, or sex control breeding techniques, and to apply novel varieties throughout the country.  

Recent Publication 

[1] Wang Y, Li XY, Xu WJ, Wang K, Wu B, Xu M, Chen Y, Miao LJ, Wang ZW, Li Z, Zhang XJ, Yin Z, Zhou BT, Yang YL, Zhu CL, Hu ML, Zheng JM, Feng CG, Qiu Q, Tian LT, Lu M, Peng F, Lu WJ, Tong JF, Tong JG, Fu BD, Yu P, Ding M, Gan RH, Zhang QQ, Jian JB, Zhang C, He WM, Yang W, Zhao ZC, Zhang QQ, Gao Q, Xu JY, Bai MZ, Zhang YP, Yang HM, Fang XD, Wang W, Zhou L, Gui JF. 2022. Comparative genome anatomy reveals evolutionary insights into a unique amphitriploid fish. Nat. Ecol. Evol., doi: 10.1038/s41559-022-01813-z 

[2] Lu LF, Jiang JY, Du WX, Wang XL, Li ZC, Zhou XY, Zhang C, Mou CY, Chen DD, Li Z, Zhou L, Gui JF, Li XY, Li S. 2022. Fish female-biased gene cyp19a1a leads to female antiviral response attenuation between sexes by autophagic degradation of MITA. PLoS Pathog., 18: e1010626.  

[3] Wang MT, Li Z, Ding M, Yao TZ, Yang S, Zhang XJ, Miao C, Du WX, Shi Q, Li S, Mei J, Wang Y, Wang ZW, Zhou L, Li XY, Gui JF. 2022. Two duplicated gsdf homeologs cooperatively regulate male differentiation by inhibiting cyp19a1a transcription in a hexaploid fish. PLoS Genet., 18(6):e1010288.  

[4] Gui JF, Zhou L, Li XY. 2022. Rethinking fish biology and biotechnologies in the challenge era for burgeoning genome resources and strengthening food security. Water Biol. Secur., 1, 100002 

[5] Gan RH, Wang Y, Li Z, Yu ZX, Li XY, Tong JF, Wang ZW, Zhang XJ, Zhou L, Gui JF. 2021. Functional divergence of multiple duplicated foxl2 homeologs and alleles in a recurrent polyploid fish. Mol Biol Evol., 38(5):1995-2013. 

[6] Ding M, Li XY, Zhu ZX, Chen JH, Lu M, Shi Q, Wang Y, Li Z, Zhao X, Wang T, Du WX, Miao C, Yao TZ, Wang MT, Zhang XJ, Wang ZW, Zhou L, Gui JF. 2021. Genomic anatomy of male-specific microchromosomes in a gynogenetic fish. PLoS Genet., 17(9):e1009760. 

[7] Lu M, Li XY, Li Z, Du WX, Zhou L, Wang Y, Zhang XJ, Wang ZW, Gui JF. 2021. Regain of sex determination system and sexual reproduction ability in a synthetic octoploid male fish. Sci China Life Sci., 64(1):77-87.  

[8] Yu P, Wang Y, Yang WT, Li Z, Zhang XJ, Zhou L, Gui JF. 2021. Upregulation of the PPAR signaling pathway and accumulation of lipids are related to the morphological and structural transformation of the dragon-eye goldfish eye. Sci China Life Sci., 64(7):1031-1049. 

[9] Zhou YL, Wang ZW, Guo XF, Wu JJ, Lu WJ, Zhou L, Gui JF. 2021. Construction of a high-density genetic linkage map and fine mapping of QTLs for growth and sex-related traits in red-tail catfish (Hemibagrus wyckioides). Aquaculture, 531, 735892. 

[10] Wang T, Li Z, Yu ZX, Wang Z W, Lian ZQ, Du WX, Zhao X, Wang MT, Miao C, Ding M, Wang Y, Zhou L, Zhang XJ, Li XY, Gui JF. 2021. Production of YY males through self-fertilization of an occasional hermaphrodite in Lanzhou catfish (Silurus lanzhouensis). Aquaculture, 539:736622.