Center for Fish Biology and Fishery Biotechnology

Research Group of Healthy Aquaculture




PI: Prof. LI Aihua, PhD

Members: Dr. ZHANG Jinyong, GONG Xiaoning, etc.   

General Introduction: 

The main research areas of the Research Group of Healthy Aquaculture are the pathogenesis of bacterial diseases of aquatic economic animals and their immunological and ecological disease prevention technology. Its objective is to provide technologies and products for the prevention and control of aquacultured animal diseases in order to improve the disease resistance of farmed animals, to reduce the incidence of diseases so as to reduce the use of antibiotics and chemicals in aquaculture, and to provide the theoretical basis and technical guarantee for the establishment of pollution-free, high-quality and efficient fishery model in China. 

Specific research directions: starting from the relationship between aquatic economic animals, pathogens and environment, the following aspects of research are carried out for important bacterial diseases. 

*    Identification and molecular pathogenic mechanisms of pathogens of emerging infectious diseases. 

*     The etiology and epidemiology of the bacterial diseases. 

*     Rapid disease diagnosis technology. 

*     Environmental regulation and immunological control technology research and development of bacterial diseases. 

*     The relationship between microbiota and aquatic animal health. 

*     Antimicrobial resistance (AMR) of aquatic bacteria and its epidemiology. 

*     Research and development of alternatives to antibiotics. 

Recent Publications:  

1.  Aihua Li & Kurt Buchmann. Temperature and salinity dependent development of a Nordic strain of Ichthyophthirius multifiliis from rainbow trout. Journal of Applied Ichthyology,2001,176):273~276. 

2.  Michael Dalgaard,Kurt Buchmann & Aihua Li. Immunization of rainbow trout fry with of Ichthyophthirius multifiliis sonicateprotection of host and immunological changes. Bulletin of the European Association of Fish Pathologists,2002,225):288~297.  

3.  Li AH, Y Kong, SH Cho, HW Lee, B K Na, JK Pak & TS Kim. Molecular cloning and characterization of the copper/zinc and manganese superoxide dismutase genes from the human parasite Clonorchis sinensis. Parasitology,2005,130687~697. 

4.  Li A.H., Na B.K., Kong Y., Cho S.H., Zhao Q.P. & Kim T.S. 2005. Molecular cloning and characterization of copper/zinc-superoxide dismutase of Paragonimus westermani. Journal of Parasitology,2005,91293~299. 

5.  Wenbo Wang, Aihua Li, Taozhen Cai & Jianguo Wang. Effects of intraperitoneal injection of cortisol on non-specific immune functions of Ctenopharyngodon idellus. Journal of Fish Biology,2005,67:779~793. (通讯作者) 

6.  Li AH, Moon SU, Park YK, Na BK, Hwang MG, Oh CM, Cho SH, Kong Y, Kim TS & Chung PR. Identification and characterization of a cathepsin L-like cysteine protease from Taenia solium metacestode. Veterinary Parasitology,2006,141251–259 

7.  Aihua Li,Wuming Yang,Jin Hu,Wenbo Wang,Taozen Cai & Jianguo Wang. Optimization by orthogonal array design and humoral immunity of the bivalent vaccine against Aeromonas hydrophila and Vibrio fluvialis infection in crucian carp. Aquaculture Research,2006,37813~820. (通讯作者) 

8.  Wenbo Wang,Yaping Wang,Wei Hu, Aihua Li, Taozhen Cai, Zuoyan Zhu, Jianguo Wang. Effects of the “all-fish”growth hormone transgene expression on non-specific immune functions of common carp. Aquaculture,2006,259:81~87. 

9.  Daling Zhu, Aihua Li, Jianguo Wang,Ming Li,Taozhen Cai. 2007. Cloning, expression and characterization of aerolysin from Aeromonas hydrophila in Escherichia coli. Indian Journal of Biochemistry & Biophysics,44204208.  

10. Jinyu Liu, Wuming Yang, Cheng Ji, Aihua Li. First description of a novel lactic acid bacterium Weissella sp. isolated from diseased rainbow trout Oncorhynchus mykiss (Walbaum) in China. Veterinary Microbiology , 2009,136: 314–320. (通讯作者) 

11.  Wuming Yang, Aihua Li. Isolation and characterization of Streptococcus dysgalactiae from diseased Acipenser schrenckii. Aquaculture, 2009.294:14-17. (通讯作者) 

12.  Defeng Zhang, Aihua Li, Jun Xie & Cheng Ji. In vitro antibacterial effect of berberine hydrochloride and enrofloxacin to fish pathogenic bacteria. Aquaculture Research, 2010,41:1095-1100. (通讯作者) 

13.  Li AH, Na BK, Ahn SK, Cho SH, Pak JH, Park YK, Kim TS. Functional expression and characterization of a cytosolic copper/zinc/superoxide dismutase of Spirometra erinacei. Parasitology Research, 2010,106(3):627-635. (通讯作者) 

14.  JinYu Liu, Ai Hua Li, Dong Ren Zhou, Zhou RuiWen & Xue PingYe. Isolation and characterization of Edwardsiella ictaluri strains as pathogens from diseased yellow catfish Pelteobagrus fulvidraco(Richardson) cultured in China. Aquaculture Research, 2010,41:1835-1844. (通讯作者) 

15.  Zhang, J. Y., Yokoyama, H., Wang, J. G., Li, A. H., Gong, X. N., Ryu-Hasegawa, A., Iwashita, M., Ogawa, K. 2010. Utilization of tissue habitats by Myxobolus wulii Landsberg & Lom, 1991 in different carp hosts and disease resistance in allogynogenetic gibel carp: redescription of M. wulii from China and Japan. Journal of Fish Diseases, 33: 57-68. 

16.  Zemao Gu, Jiangguo Wang, Xiaoli Ke, Yang Liu, Xiaoling Liu, Xiaoning Gong, Aihua Li. Phylogenetic position of the freshwater fish trypanosome, Trypanosoma ophiocephali (kinetoplastida) inferred from the complete small subunit ribosomal RNA gene sequence. Parasitology Research, 2010, 106:1039-1042. 

17.   Ji Cheng, Li Aihua, Xie Jun, Zhang Defeng & Liu Jinyu. Bactericidal activity of grass carp Ctenopharyngodon idella C9-deficient serum against Aeromonas hydrophila. Journal of Fish Biology (2011) 79, 2083–2086. (通讯作者) 

18.  Cheng Ji, De Feng Zhang, Ai Hua Li, Xiao Ning Gong. Effect of berberine hydrochloride on grass carp Ctenopharyngodon idella serum bactericidal activity against Edwardsiella ictaluri. Fish & Shellfish Immunology, 2012,33 (1):143-145. (通讯作者) 

19.  Liu Jinyu & Li Aihua. First case of Aeromonas schubertii infection in the freshwater cultured snakehead fish, Ophiocephalus argus (Cantor), in China. Journal of Fish Diseases 2012, 35, 335–342. (通讯作者) 

20.  Xu-Jie Zhang, Wu-Ming Yang, De-Feng Zhang, Tong-Tong Li, Xiao-Ning Gong & Ai-Hua  Li. Does the gastrointestinal tract serve as the infectious route of Aeromonas hydrophila in crucian carp (Carassius carassius)? Aquaculture Research, 2013, 1–14(通讯作者) 

21.  Defeng Zhang, Aihua Li, Yujuan Guo, Qianqian Zhang, Xuenian Chen, Xiaoning Gong. Molecular characterization of Streptococcus agalactiae in diseased farmed tilapia in China. Aquaculture, 2013,412–413:64–69. (通讯作者) 

22.  Li Juan Zhao, Jin Fang Lu, P. Nie, Ai Hua Li, Bang Xi Xiong, Hai Xia Xie. Roles of plasmid-encoded proteins, EseH, EseI and EscD in invasion, replication and virulence of Edwardsiella ictaluri. Veterinary Microbiology, 2013,166 :233–241. 

23.  Bao-Qing Hu , Yi Liu , Chun-Gen Wen , Ai-Hua Li , Xiang-Ping Hu, Dan Wu, Xiao-Juan Hu, Zhi-Ying Tao. Cloning and expression of selenoprotein W from pearl mussels Cristaria plicata. Comparative Biochemistry and Physiology Part B20141678-15(通讯作者). 

24.  Zhang Defeng, Zhang Qianqian & Li Aihua. Development of a multiplex PCR assay for rapid and simultaneous detection of four genera of fish pathogenic bacteria. 2014, Letters in Applied Microbiology, 2014:59(5):471-478.doi: 10.1111/lam.12303 (通讯作者) 

25.  Xujie Zhang, Wuming Yang, Han Wu, Xiaoning Gong, Aihua Li. Multilocus sequence typing revealed a clonal lineage of Aeromonas hydrophila caused motile Aeromonas septicaemia outbreaks in pond cultured cyprinid fish in an epidemic area, central China. Aquaculture, 2014, 32: 1–6. (通讯作者) 

26.  Tongtong Li, Meng Long ,Fran?ois-Jo?l Gatesoupe, Qianqian Zhang, Aihua Li & Xiaoning Gong. Comparative analysis of the intestinal bacterial communities in different species of carp by pyrosequencing. Microbial Ecology, 2014 DOI 10.1007/s00248-014-0480-8(通讯作者) 

27.  授权的专利。李爱华, 王文博, 蔡桃珍, 吴玉深。刺五加在水产养殖中的应用。专利号:ZL 02115834.7  2005216授权。 

28.  杨先乐,李爱华等。鱼类药理学。农业出版社(“十一五”高校统编教材)(参编)。2011 

29.  2011年、2012年和2013年全国职业兽医资格考试应试指南(水生动物类)       编著。中国农业出版社。