Center for Molecular and Cellular Biology of Aquatic Organisms

Research Group on Fish Development and Stem Cell Biology


PI: Prof. SUN Yuhua, PhD

Staff and students 

postdoctoral fellow:  Xiaoyun Sun; 

Ph.D students:   Xixia Peng 

M.Sc. students:  Yanyong Zhang, Fangjing Rong 

Contact Us:  

Prof. Yuhua Sun(email: 

Research Group on Fish Development and Stem Cell Biology 

Institute of Hydrobiology, the Chinese Academy of Sciences 

7# South Donghu Road, Wuhan, Hubei, China, 430072 

Tel: +86-27-68780718 

General Introduction 

Established in 2015, the Research Group of Fish Development and Stem Cell Biology focuses on both basic questions in developmental biology and mechanism study of aquatic animal and human diseases, using zebrafish and mammalian pluripotent stem cells.  

Utilizing the power of genetics, molecular biology, genomics and bioinformatics, their research area includes:  

* Neural and gonadal stem cell development and related diseases 

* Stem cell fate determination, gene expression control and stem cell maintenance and differentiation 

* Mechanism study of major aquatic animal diseases, and development of disease resistant lines 

* The molecular mechanisms underlying major human diseases, particular neurodegenerative disorders and cardiovascular diseases 

* Isolation and culturing of aquatic animal gonadal stem cells  

Since 2015, this group has made major progress in these areas, and results have been published in international journals, including Nature Communications, Frontiers in Cell and Developmental Biology.   

Recent Publications:

       Ryan Berger, Yuhua Sun et al., (2016). ST8SIA4-dependent polysialylation is part of a developmental program required for germ layer formation from human pluripotent stem cells. Stem Cells, DOI: 10.1002/stem.2379     

  Amar Singh*, Yuhua Sun*, Li Li, Steve Qin, and Steve Dalton (2015). Cell-Cycle  Control of Bivalent Epigenetic Domains Regulates the Exit from Pluripotency. Stem Cell Reports3:323 (*equal contribution)     

  Yuhua Sun, Weichia Tseng, Rebecca Ball,and Scott Dougan (2014). Extra-embryonic signals under the control of Mga, Max and Smad4 are required for dorsoventral patterning. Developmental Cell, 28: 322     

  J Champell*, YH Sun*, A Singh, S Dalton (2013). Myc/Max control Erk signaling and pluripotency by regulation of dual specificity phosphatases 2 and 7. Genes & Development (*equal contribution), 27:725-733     

  J Phillips-Cremins, M Sauria, A Sanyal, T Gerasimova, B Lajoie, J Bell, CT Ong, T Hookway, C Guo, YH Sun, M Bland, W Wagstaff, S Dalton, T McDevitt, R Sen, J Dekker, J Taylor, V Corces (2013)Architectural protein subclasses shape 3- D organization of genomes during lineage commitment.Cell, 153: 1281     

  Amar M. Singh, David Reynoids, Timothy Cliff, Satoshi Ohtsuka, Alexa Mattheyses, Yuhua Sun, Laura Menendez, Michael Kulik and Stephen Dalton (2012). Signaling Network Crosstalk in Human Pluripotent Cells: A Smad2/3-Regulated Switch that Controls the Balance between Self-Renewal and Differentiation. Cell stem cell, 10(3): 312-326   

  Sun YH, Wloga D. and Dougan S. (2011). Embryological manipulations in zebrafish. Methods Mol. Biol., 770: 139-184     

  D.M. Webster, C.F. Teo, YH. Sun, D. Wloga, S. Gay, L. Wells and S. T. Dougan (2009). O-GlcNAc modifications regulate cell survival and epiboly during zebrafish development. BMC Dev. Biol., 9(1): 28-33 Highly Accessed Article     

  Chengtai Yang, Ling Cao, Weimin Wang, Yi Yang, Binlun Yan, Li Su, Yuhua Sun, and Huanling Wang (2009). Comparative and evolutionary analysis in natural diploid and tetraploid weather loach Misgurnus anguillicaudatus based on cytochrome b sequence data in central China. Environmental Biology of Fishes, 86(1): 145-153    

  Treer T., Sprem N, Torcu-Koc, YH Sun, and M. Piria (2008). Length-weight relationship of freshwater fishes of Croatia. J. Appl. Ichthyol, 24: 626-628   

  Yuhua Sun, Rong Tang, Dapeng Li, Xuezhen Zhang, Juan Fu, Ping Xie (2008). Acute effects of microcystins on transcription of antioxidant enzyme genes in crucian carp. Environ. Toxicol., 23: 145-152     

  Zexia Gao, *Weimin Wang, Khalid Abbas, Xiaoyun Zhou, Yi Yang, James S Diana, Hanping Wang, Huanling Wang, Yang Li, Yuhua Sun (2007). Haematological characterization of loach Misgurnus anguillicaudatus: comparison among diploid, triploid and tetraploid specimens. Comp Biochem Physiol A Mol Integr Physiol. 2007 Aug;147-   

  YH Sun, CX Xie, WM Wang, SY Liu, T. Treer, MM Chang et al (2007). The genetic variation and the biogeography of catostomid fishes based on mitochondrial and nucleic DNA sequences. Journal of Fish Biology, 70: 291-309      

  Yuhua Sun, Siyang Liu, Gang Zhao, QX Yu et al (2004). Population structure of Chinese sucker Myxocyprinus asiatus (Cypriniformes: Catostomidae) in the Yangtze River based on Mitochondrial DNA control region sequences. Fisheries Science, 70(3): 412-420     

  SUN Yu-Hua; WANG Wei; LIU Si-Yang; HE Shun-Ping; SHAO Xue-Ling; XIE Zhi-Xiong; DENG Feng-Jiao; LIU Yong; TONG Jin-Gou; WU Qing-Jiang (2002). Genetic Diversity Analysis of Mitochondrial D-loop Region of Chinese Sucker (Myxocyprinus asiaticus). Journal of Genetics and Genomics (in Chinese), 29(9): 787-790