Research

Center for Molecular and Cellular Biology of Aquatic Organisms

Research Group of Environmental Genomics

  

 
 

 

PI: Prof. CUI Zongbin, PhD

Members: Jie Li, Yong Long, Hanqiao Shang, Guili Song, Yuan Yuan Li, Guohui Feng, Chunyan Liu, Qing Li, Zongbin Cui 

Contact Us:  

Tel: 86-27-68780090 

Fax: 86-27-68780090 

Email: zbcui@ihb.ac.cn
Postal address: Institute of Hydrobiology, Chinese Academy of Sciences. #7 Donghu South Rd, Wuhan, Hubei, 430072, P. R. China
 

General Introduction:  

Established in 2006, the Research Group of Environmental Genomics focuses on the study of the molecular regulatory mechanism and signal transduction of cold resistance, organ development and regeneration by using common carp, tilapia and zebrafish as models.  

Their main research include the identification of the functional genes and genetic sites related to cold resistance in fish and dissection of the mechanism of low-temperature signal transduction; function and regulation mechanisms of key signal pathways in zebrafish embryonic development and liver regeneration; development and application of fish mucous gland bioreactor.  

This group published more than 40 research papers in Hepatology, JBC, BMC genomics and other peer-reviewed journals. They also trained a total of 19 postdoctoral and doctoral/master graduates and jointly trained five doctoral/master degree graduates. A total of more than 25 million RMB was obtained from the national major R&D program, the National Natural Science Foundation of China, and the pilot project of the Chinese Academy of Sciences. 

Main research results:  

* Revealed the transcriptional regulation events of zebrafish larvae during low temperature adaptation and identified the early regulatory factors in cold stress response     

* Identified a new NO-AMPK-PPARa signaling pathway that plays an important role in the regulation of fatty acid metabolism in zebrafish liver cells 

* Established a new bioreactor based on mucus cells of loach skin 

Recent Publications:  

[1]Yong Long, Linchun Li, Qing Li, Xiaozhen He, Zongbin Cui*, 2012. Transcriptomic characterization of temperature stress responses in larval zebrafish. PLoS ONE, doi:10.1371/journal.pone.0037209(*Corresponding Author) 

[2] Rui Wen, Jie Li, Xin Xu, Zongbin Cui*, Wei Xiao*, 2012. Zebrafish Mms2 promotes K63-linked polyubiquitination and is involved in p53-mediated DNA-damage response. DNA Repair. 11(2): 157-166(*Corresponding Author) 

[3] Yuanyuan Li, Qing Li, Yong Long, Zongbin Cui*, 2011. Lzts2 regulates embryonic cell movements and dorsoventral patterning through interaction with and export of nuclear b-catenin in zebrafish. Journal of Biological Chemistry, 286(52): 45116-45130(*Corresponding Author) 

[4]Hanqiao Shang, Qing Li, Guohui Feng, Zongbin Cui*, 2011. Identification and characterization of alternative promoters, transcripts and protein isoforms of zebrafish R2 gene. PLoS ONE 6(8): e24089. doi:10.1371/journal.pone.0024089 (*Corresponding Author). 

[5]Yong Long, Qing Li, Youhui Wang, Zongbin Cui*, 2011. MRP proteins as potential mediators of heavy metal resistance in zebrafish cells. Comp. Biochem.Physiol. C, 153: 310–317(*Corresponding Author) 

[6] Yong Long, Qing Li, Zongbin Cui*, 2011. Molecular analysis and heavy metal detoxification of ABCC1/MRP1 in zebrafish.Molecular Biology Reports, 38:1703–1711(*Corresponding Author) 

[7] Hanqiao Shang, Qing Li, Guohui Feng, Zongbin Cui*, 2011. Molecular analysis and functions of p53R2 in zebrafish. Gene, 475: 30-38(*Corresponding Author) 

[8] Yong Long, Qing Li, Jie Li, Zongbin Cui*, 2011. Molecular analysis, developmental function and heavy metal-induced expression of ABCC5 in zebrafish. Comp.Biochem. Physiol. B, 158(1): 46–55 (*Corresponding Author) 

[9] Yong Long, Qing Li, Youhui Wang, Zongbin Cui*, 2011. Molecular characterization and functions of zebrafish ABCC2 in cellular efflux of heavy metals. Comp.Biochem.Physiol. C,153(4):381-391(*Corresponding Author). 

[10]Saijun Mo, Shengli Yang, Zongbin Cui*,2011.New glimpses of caveolin-1 functions in embryonic development and human diseases. Frontiers in Biology, 6(5):367-376(* Corresponding Author) 

[11] Saijun Mo, Lu Wang, Qing Li, Jie Li , Yuanyuan Li, Victor J. Thannickal, Zongbin Cui*, 2010. Caveolin-1 regulates dorsoventral patterning through direct interaction with β-catenin in zebrafish. Developmental Biology, 344: 210–223 (*Corresponding Author) 

[12] Jie Li, Rui Wen, Parkeer Andersen, Yuping Liang, Qing Li, Wei Xiao, Zongbin Cui*, 2010. Zebrafish Ubc13 is required for Lys63-linked polyubiquitination and DNA damage tolerance. Molecular and Cellular Biochemistry, 343:173–182 (*Corresponding Author)