Center for Molecular and Cellular Biology of Aquatic Organisms

Research Group of Fish Molecular Endocrinology




PI: Prof. YIN Zhan, PhD

Members: Jiangyan He (M.Sc., Associate Professor) 

     Qiyong Lou (Assistant Professor) 

     Gang Zhai (Assistant Professor) 

                   Xia Jin (Experimentalist) 

Contact Us:  

Zhan Yin: 86-27-68780069 (Telephone and Fax, Office) 

     86-27-68780082 (Telephone) 

General Introduction:  

The Research Group of Fish Molecular Endocrinology is interested in the use of zebrafish as model to study molecular endocrine pathways involved in somatic growth, metabolism and sexual development in cyprinids fish, including growth hormone, myostatin, Insulin/PI3K/Akt signaling, Pomc signaling, thyroid hormone and sex steroids signaling.  

To elucidate the role of these pathways in the effector organs (such as liver, muscle, adrenal gland, and gonad), the energy homeostasis and nutrient utilization, stress and ingestion, gonadal development and differentiation, as well as the sexual dimorphic in metabolism were investigated.  

Meanwhile, the molecular marker-assisted genetic selection and breeding, as well as gene editing-mediated precious endocrinology screening were applied to farmed fish, Yellow river Carp and Crucian Carp. The fish lines generated in their lab are with elevated feed conversion efficiency or fast growth in sex biased population or enhanced muscular growth show high potential in future sustainable fisheries.  

Their research works were published in Cell Reports, Science Bulletin, Redox Biology, Endocrinology, Journal of Molecular and Cell Biology etc. The group leader, Professor YIN Zhan was funded by the National Key Research and Development Program of China, National Natural Science Foundation of China and Pilot Program (A Project) from the Chinese Academy of Sciences. 

Recent Publications:  

1.        Gao Y, Dai Z, Shi C, Zhai G, Jin X, He J, Lou Q and Yin Z* (2016) Depletion of Myostatin b Promotes somatic growth and lipid Metabolism in Zebrafsh Front. Endocrinol. 7:88. doi: 10.3389/fendo.2016.00088. 

2.        Gang Zhai, Tingting Shu, Yuguo Xia, Xia Jin, Jiangyan He and Zhan Yin* 2016Androgen signaling regulates the transcription of anti-Müllerian hormone via synergy with SRY-Related Protein SOX9A  Science BulletinIn Press. 

3.        Yuqin Shu , Qiyong Lou, Ziru Dai, Xiangyan Dai, Jiangyan He, Wei Hu & Zhan Yin * 2016 The basal function of teleost prolactin as a key regulator on ion uptake identified with zebrafish knockout models  Scientific Reports 6, Article number: 18597 (2016) 

4.        Dai Z, Wang H, Jin X, Wang H, He J, Liu M, Yin Z, Sun Y, Lou Q. 2015 Depletion of suppressor of cytokine signaling-1a causes hepatic steatosis and insulin resistance in zebrafish. Am J Physiol Endocrinol Metab. 2015 May 15;308(10):E849-59. doi: 10.1152/ajpendo.00540.2014. Epub 2015 Mar 10. 

5.        Dai X, Jin X, Chen X, He J, Yin Z*. 2015 Sufficient numbers of early germ cells are essential for female sex development in zebrafish. PLoS One. 2015 Feb 13;10(2):e0117824. doi: 10.1371/journal.pone.0117824. eCollection 2015. 

6.        Dai X, Zhang W, Zhuo Z, He J, Yin Z*. (2015) Neuroendocrine regulation of somatic growth in fishes. Sci China Life Sci. 2015 Feb;58(2):137-47. doi: 10.1007/s11427-015-4805-8. Epub 2015 Feb 7. Review. 

7.        Cheng X, Chen X, Li D, Jin X, He J, Yin Z*  2015 .Effects of metronidazole on proopiomelanocortin a gene expression in zebrafish. Gen Comp Endocrinol. 2015 Apr 1;214:87-94. doi: 10.1016/j.ygcen.2014.05.029. Epub 2014 Jun 4. 

8.        Cheng, X., Chen, X., Jin, X., He, J., Yin, Z*. 2014. Generation and Characterization of Gsuα:EGFP Transgenic Zebrafish for Evaluating Endocrine-Disrupting Effects. Toxicology and Applied Pharmacology. 278 78–84 

9.        He, W., Dai, X., Chen, X., He, J., Yin, Z*. 2014. Zebrafish Pituitary Gene Expression Before and After Sexual Maturation. Journal of Endocrinology. 221 

10.    Li, D., Lou, Q., Zhai, G., Peng, X., Cheng, X., Dai, X., Zhuo, Z., Shang, G., Jin, X., Chen, X., Han, D., He, J., Yin, Z.* 2014. Hyperplasia and Cellularity Changes in IGF-1-Overexpressing Skeletal Muscle of Crucian Carp. Endocrinology. 155(6):2199–221.   

11.    Zhai, G., Gu, Q., He, J., Lou, Q., Chen, X., Jin, X., Bi, E., Yin, Z.* 2014. Sept6 is required for ciliogenesis in Kupffer's vesicle, pronephros and neural tube during early embryonic development. Molecular and Cellular Biology. 34(7): 1310-1321.   

12.    Mei Y, Yin N, Jin X, He J, Yin Z* 2013 The regulatory role of the adrenergic agonists phenylephrine and isoproterenol on fetal hemoglobin expression and erythroid differentiation. Endocrinology. 154(12):4640-9. 

13.    Chen D, Li L, Tu X, Yin Z*, Wang Q.2013 Functional characterization of Klippel-Trenaunay syndrome gene AGGF1 identifies a novel angiogenic signaling pathway for specification of vein differentiation and angiogenesis during embryogenesis. Hum Mol Genet. 22(5):963-76.  

14.    Cui X, Zhang J, Du R, Wang L, Archacki S, Zhang Y, Yuan M, Ke T, Li H, Li D, Li C, Li DW, Tang Z, Yin Z*, Liu M. 2012 HSF4 is involved in DNA damage repair through regulation of Rad51.Biochim Biophys Acta. 1822(8):1308-15. 

15.    Ji C., Jin X., He J.& Yin, Z*. 2012  Use of TSHbeta:EGFP transgenic zebrafish as a rapid in vivo model for assessing thyroid-disrupting chemicals. Toxicol. Appl. Pharmacol. 262(2):149-155 

16.    Jiang N., Jin X., He J. & Yin Z*. 2012 The Roles of follistatin 1 in Regulation of Zebrafish Fecundity and Sexual Differentiation  Biol Reprod  87 (3) 54, 1-8 

17.    Chen X., Lou Q., He J. & Yin Z*. 2012  Role of Zebrafish Lbx2 in Embryonic Lateral Line Development . PLoS ONE 6(12): e29515. 

18.    Lou Q., He J., Hu L.& Yin Z*.  2012  Role of lbx2 in the noncanonical Wnt signaling pathway for convergence and extension movements and hypaxial myogenesis in zebrafish Biochim Biophys Acta. 823(5):1024-32 

19.    Li X., He J., Hu W & Yin Z * 2009  The essential role of endogenous ghrelin in growth hormone expression during zebrafish adenohypophysis development. Endocrinology 150(6):2767-74 

20.    Ma L., Li D., Wang J., He J & Yin Z * 2009. Effects of Adrenergic Agonists on the Extrahepatic Expression of Vitellogenin Ao1 in Heart and Brain of the Chinese Rare Minnow (Gobiocypris rarus)。 Aquatic Toxicol. 91 (1): 19-25.  

21.    Trivedi CM*, Luo Y*, Yin Z*, Zhang M, Zhu W, Wang T, Floss T, Goettlicher M, Noppinger PR, Wurst W, Ferrari VA, Abrams CS, Gruber PJ, Epstein JA. (2007). HDAC2 regulates the cardiac fetal gene program and hypertrophic responsiveness by modulating GSK3?. Nature Medcine. 13(3): 324-331. (Equal first author).  

22.    Yin, Z. Haynie, J., Yang, X.,. Han, B., Kiatchoosakun, S., Restivo, J., Yuan, S., Prabhakar, N. R., Herrup, K., Conlon, R. A., Hoit, B. D., Watanabe, M and Yu-Chung Yang. 2002  The essential role of Cited2, a negative regulator hif-1 in heart development and neurulation.  PNAS 99, 10488-10493.    

Last updated on Oct.18, 2016