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  • Research Group of Protozoan Functional Genomics
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     Prof. Wei MIAO

    Principal Investigator: Prof. Wei MIAO, PhD 

    Members: Jie XIONG, Dongxia YUAN;Graduate students: Yue CHANG, Miao TIAN, Qiuping ZHONG, Guangying WANG, Jing ZHANG 

    Contact Us: Institute of Hydrobiology(IHB), Chinese Academy of Sciences(CAS), 7 Donghu South Road, Wuhan, 430072, Hubei, P.R.China;      

    Tel/Fax: +86 (0)27-68780050  

    General Introduction:  

    The laboratory of Protozoan Functional Genomics at the Institute of Hydrobiology (IHB), Chinese Academy of Sciences (CAS) was founded in 2009, and tracked from the well-reputed research group of Protozoan taxonomy and ecology which was founded by academician Jiaji WANG and further developed by academician Yunfen SHEN and Prof. Yuhe YU.  

    Our research interests focus on the functional genomics of model organism, Tetrahymena and other protozoan species, with the aims of: 1)investigating the unique mechanisms of molecular evolution, functional divergence and ecological adaptation in the unicellular eukaryotes at the genomics level; 2)studying the basic metabolism pathways or regulation networks that are conserved among the eukaryotic organisms.    

     

     Chief Members

     

    Currently, there are four main research directions:  

    1)Evolutionary Genomics & Phylogenomics of Protozoan —— based on sequencing and analyzing the omics data from typical species of ciliate groups and free-living/parasitic/mutualistic ciliates, studying the phylogeny and adaptive evolution among ciliates, further discussing the evolutionary biology of unicellular eukaryotes;  

    2)Evolutionary & Ecological Functional Genomics (EEFG) of Tetrahymena —— based on sequencing and analyzing the omics data from more than ten species among genus Tetrahymena, studying the comparative genomics and the experimental evolutionary genomics of Tetrahymena, further discussing the speciation, ecological adaptation and reproductive evolution etc. of unicellular eukaryotes;  

    3)Epigenomics of Tetrahymena —— based on the omics data and experimental biological technique, studying the functions of histone modification and Small RNA on DNA replication and meiosis, further discussing the epigenetic mechanism involved in nuclear events of eukaryotes; 

    4)Genetic Engineeringof Tetrahymena —— based on the Tetrahymena expression system and genetic resources of ciliates, developing the biosensor and bioreactor for monitorring/degrading the pollutants and producing the vaccin of ciliate diseases. 

    Recent Publications:  

    (1)Cervantes MD, Hamilton EP, Xiong J, Lawson MJ, Yuan D, Hadjithomas M, Miao W*, Orias E*. 2013. Selecting One of Several Mating Types through Gene Segment Joining and Deletion in Tetrahymena thermophila [J]. Plos Biology, 11(3): e1001518. 

    (2)Xiong J, Lu YM, Feng JM, Yuan DX, Tian M, Chang Y, Fu CJ, Wang GY, Zeng HH*, Miao W*, Tetrahymena Functional Genomics Database (TetraFGD): an integrated resource for Tetrahymena functional genomics. Database. 2013 : bat008 

    (3)Xiong J, Lu XY, Zhou ZM, Chang Y, Yuan DX, Tian M, Zhou ZG, Wang L, Fu CJ, Orias E, Miao W*. 2012. Transcriptome Analysis of the Model Protozoan, Tetrahymena Thermophila, Using Rna-Seq [J]. Plos One, 7(2): e30630. 

    (4)Xiong J, Yuan D, Fillingham JS, Garg J, Lu X, Chang Y, Liu Y, Fu C, Pearlman RE, Miao W*. 2011. Gene Network Landscape of the Ciliate Tetrahymena Thermophila [J]. Plos One, 6(5): e20124. 

    (5)Chang Y, Feng LF, Miao W*. 2011. Toxicogenomic Investigation of Tetrahymena Thermophila Exposed to Dichlorodiphenyltrichloroethane (DDT), Tributyltin (TBT), and 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (TCDD) [J]. Sci China Life Sci, 54(7): 617-625. 

    (6)Xiong J, Feng L, Yuan D, Fu C, Miao W*. 2010. Genome-Wide Identification and Evolution of Atp-Binding Cassette Transporters in the Ciliate Tetrahymena Thermophila: A Case of Functional Divergence in a Multigene Family [J]. Bmc Evol Biol, 10: 330. 

    (7)Fu C, Xiong J, Miao W*. 2009. Genome-Wide Identification and Characterization of Cytochrome P450 Monooxygenase Genes in the Ciliate Tetrahymena Thermophila [J]. BMC Genomics, 10:208. 

    (8)Miao W*, Xiong J, Bowen J, Wang W, Liu Y, Braguinets O, Grigull J, Pearlman RE, Orias E, Gorovsky MA*. 2009. Microarray Analyses of Gene Expression During the Tetrahymena Thermophila Life Cycle [J]. Plos One, 4(2): e4429. 

    (9)Guo L, Fu C, Miao W*. 2008. Cloning, Characterization, and Gene Expression Analysis of a Novel Cadmium Metallothionein Gene in Tetrahymena Pigmentosa [J]. Gene, 423(1): 29-35. 

    (10)Feng LF, Miao W*, Wu YX. 2007. Difterentially Expressed Genes of Tetrahymena Thermophila in Response to Tributyltin (TBT) Identified by Suppression Subtractive Hybridization and Real Time Quantitative Pcr [J]. Aquatic Toxicology, 81(1): 99-105. 

    (11)Fu CJ, Miao W*. 2006. Cloning and Characterization of a New Multi-Stress Inducible Metallothionein Gene in Tetrahymena Pyriformis [J]. Protist, 157(2): 193-203. 

    (12)Miao W*, Yu T, Orias E, Wan ML, Fu CJ. 2006. Identification of Differentially Expressed Genes in Tetrahmena Thermophila in Response to Dichlorodiphenyltrichloroethane (DDT) by Suppression Subtractive Hybridization [J]. Environmental Microbiology, 8(6): 1122-1129. 

    (13)Miao W, Simpson AGB, Fu CJ, Lobban CS. 2005. The Giant Zooxanthellae-Bearing Ciliate Maristentor Dinoferus (Heterotrichea) Is Closely Related to Folliculinidae [J]. J Eukaryot Microbiol, 52(1): 11-16. 

    (14)Miao W, Fen WS, Yu YH, Zhang XY, Shen YF. 2004. Phylogenetic Relationships of the Subclass Peritrichia (Oligohymenophorea, Ciliophora) Inferred from Small Subunit rRNA Gene Sequences [J]. J Eukaryot Microbiol, 51(2): 180-186. 

    (15)Miao W, Yu YH, Shen YF, Zhang XY. 2004. Intraspecific Phylogeography of Carchesium Polypinum (Peritrichia, Ciliophora) from China, Inferred from 18s-ITS1-5.8s Ribosomal DNA [J]. Sci China Ser C, 47(1): 11-17. 

    *: corresponding Author 

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