Research Group of Protozoan Functional Genomics----Institute of Hydrobiology, Chinese Academy of Sciences

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Center for Aquatic Biodiversity and Resource Conservation

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Center for Fish Biology and Fishery Biotechnology

Center for Water Environment Engineering

Center for Water Environment and Human Health

Center for Algal Biology and Applied Research

Research Group of Protozoan Functional Genomics

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Principal Investigator: Prof. Wei MIAO, PhD

Members: Chengjie FU, Dongxia YUAN；Graduate student: Lifang FENG, Jie XIONG; Yue CHANG, Xingyi LU

Contact Us:

Tel/Fax: +86-27-68780050

Institute of Hydrobiology(IHB), Chinese Academy of Sciences(CAS)

7 Donghu South Road, Wuhan,

430072, Hubei, P.R.China　　　

General Introduction:

The laboratory of Protozoan Functional Genomics at the Institute of Hydrobiology(IHB), Chinese Academy of Sciences(CAS) was founded in 2009, and tracked from the well-reputed research group of Protozoan taxonomy and ecology which was founded by academician Jiaji WANG and further developed by academician Yunfen SHEN and Prof. Yuhe YU.

Our research interests focus on the functional genomics of model organism, Tetrahymena and other protozoan species, with the aims of: 1) investigating the unique mechanisms of molecular evolution, functional divergence and ecological adaptation in the unicellular eukaryotes at the genomics level; 2) studying the basic metabolism pathways or regulation networks that are conserved among the eukaryotic organisms. 　　

Currently, there are two main research directions: 1) Tetrahymena Evolutionary & Ecological Functional Genomics; 2) Tetrahymena Epigenomics.

Recent Publications:

1.Miao W*, Xiong J, Bowen J, Wang W, Liu Y, Braguinets O, Grigull J, Pearlman RE, Orias E, Gorovsky MA. Microarray analyses of gene expression during the Tetrahymena thermophila life cycle. PLoS One. 2009, 4(2):e4429.

2.Chengjie Fu, Jie Xiong, Wei Miao*. Genome-wide identification and characterization of cytochrome P450 monooxygenase genes in the ciliate Tetrahymena thermophila. BMC Genomics. 2009, 10:208.

3. Lina Guo, Chengjie Fu, Wei Miao*.Cloning, Characterization and Gene Expression Analysis of a novel cadmium-Metallothionein Gene in Tetrahymena pigmentosa. Gene. 2008, 423(1): 29-35.

4. Lifang Feng, Wei Miao*, Yuxuan Wu. Differentially expressed genes of Tetrahymena thermophila in response to tributyltin (TBT) identified by suppression subtractive hybridization. Aquatic Toxicology. 2007, 81(1): 99-105.

5. Wei Miao*, Ting Yu, Eduardo Orias, Mingliang Wan, Chengjie Fu. Identification of differentially expressed genes in Tetrahymena thermophila in response to Dichlorodiphenyltrichloroethane (DDT) by suppression subtractive hybridization. Environmental Microbiology, 2006, 8(6): 1122-1129.

6. Chengjie Fu, Wei Miao*. Cloning and Characterisation of A Novel Cadmium-induced Metallothionein In Tetrahymena pyriformis. Protist. 2006, 57(2):193-203.

7. Wei Miao, Alastair G.B. SIMPSON, Chengjie FU, and Christopher S. LOBBAN. The giant zooxanthellae-bearing ciliate Maristentor dinoferus (Heterotrichea) is closely related to Folliculinidae. J. Eukaryot. Microbiol. 2005, 52(1):11-16.

8. Mingliang Wan, Weisong Feng,, Wei Miao*, Minghong Wong. Evolutionary Mode of Metallothioneins Inferred from Cd-MT Genes of Tetrahymena .Wuhan University Journal of Natural Sciences. 2005, (5):925-930.

9. Wei Miao, Weisong Feng, Yuhe Yu, Xiyuan Zhang, Yunfen Shen. Phylogenetic Relationships of the Subclass Peritrichia (Oligohymenophorea, Ciliophora) with Emphasis on the Order Sessilida, Inferred from Small Subunit rRNA Gene Sequences. J. Eukaryot. Microbiol. 2004,51(1): 180-186.

10. Wei Miao, Yuhe Yu,Yunfen Shen, Xiyuan Zhang. Intraspecific Phylogeography of Carchesium polypinum (Peritrichia, Ciliophora) from China, Inferred from 18S-ITS1-5.8S Ribosomal DNA. Science in China (series C), 2004, (1):10-17.