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Prof. Jack Chen from Simon Fraser University Visits IHB


Prof. Jack Chen from Simon Fraser University of Canada paid a visit to IHB on April 15th.
 

Prof. Jack Chen from Simon Fraser University of Canada paid a visit to Institute of Hydrobiology, Chinese Academy of Sciences (IHB) on April 15th.  During his visit, he gave an oral presentation with the title of “Applied Comparative Genomics” for IHB researchers and graduate students.

Prof. Chen explained the presentation from the development history of genomics, the main research work of his laboratory and the challenges in comparative genomics in three aspects. 

In the development history of genomics, Prof. Chen showed the audience the origin and development of genomics, and emphasized the Sanger method, Automated Sanger method, SGS and TGS in the important role of the development of genomics.  

He divided his research work into two parts. The first part is about the software required in the genomics research work. They have developed some software, genBlastA and genBlastG for gene finding, OrthoCluster for synteny black detection, VariationBlast, CooVar and FeatureStack for identification of GVs. The second part of the research work is divided into “Species - Specific genes and pathways in malaria parasites”, “Invasion route of pinewood nematodes” and “Finding driver mutations in cancer”. Malaria is a threat to human health, he found the pathogenicity of the malaria parasite can transfer in horizontal direction.  


In the study of pine wood nematode, Prof. Chen presented that “Super PWN” formed in Hong Kong, Guangdong and Jiangxi which are originated from the United States and Japan, finally spread to other places in China, even invade Portugal. Finally, Prof. Chen put forward some challenges in the study of comparative genomics
1, High-quality reference genome, in particular of complex genome (large biased GC content, repetitive); 2, Full-length transcript construction; 3, Regulatory elements finding; 4, Metagenomics.