PI: Prof. Dr. GUI Jian-Fang (CAS member)

Chief members: Prof. Dr. ZHOU Li, Prof. Dr. WANG Zhongwei, Prof. Dr. LI Xiyin, Asso.Prof. Dr. LU Meng, Asso.Prof.Dr. YU Peng, Senior Engineer LI Zhi, Senior Engineer ZHANG Xiaojuan, Dr. DING Miao, Dr. LIN Qiaohong, Dr. WANG Mingtao, Dr. ZHOU Yulin, 16 Ph.D students and 16 Sc.M. students.

Tel: 86-27-68780707

Email: jfgui@ihb.ac.cn

General Introduction:

Researches in this group are concentrated on three aspects. The first is attempting to reveal genetic basis of important economic traits in fish, especially focusing on gametogenesis and gynogenesis, sex determination and differentiation, immunity and disease resistance in gibel carp, and morphological variations in goldfish, and thereby to develop precise breeding biotechnologies, such as whole genome-based genotyping selection, genome reconstruction, gene edit, and sex control. The second is to perform genome reconstitution studies on polyploid fish, and thereby to reveal genetic mechanisms on genome or sub-genome integration and to exploit new biotechnology approaches for polyploid synthesis and sterile offspring creation. The third is to conduct applicable researches on novel variety breeding and promotion for sustainable aquaculture.

Keywords:

Fish genetic breeding, Precise breeding, Cell engineering, Genome and reconstruction, Gene editing

Recent Publication:

[1]     Gui JF*. Chinese wisdom and modern innovation of aquaculture. Water Biology and Security, 2024, 100271. https://doi.org/10.1016/j.watbs.2024.100271.

[2]     Lu M, Zhou L*, Gui JF*. Evolutionary mechanisms and practical significance of reproductive success and clonal diversity in unisexual vertebrate polyploids. Science China Life Sciences, 2024, 67, 449-459. https://doi.org/10.1007/s11427-023-2486-2.

[3]     Lu M, Zhang QC, Zhu ZY, Peng F, Li Z, Wang Y, Li XY, Wang ZW, Zhang XJ, Zhou L*, Gui JF*. An efficient approach to synthesize sterile allopolyploids through the combined reproduction mode of ameiotic oogenesis and sperm-egg fusion in the polyploid Carassius complex. Science Bulletin, 2023, 68(10): 1038-1050. https://doi.org/10.1016/j.scib.2023.04.029.

[4]     Gan RH, Li Z, Wang ZW, Li XY, Wang Y, Zhang XJ, Tong JF, Wu Y, Xia LY, Gao ZX*, Zhou L*, Gui JF*. Creation of intermuscular bone-free mutants in amphitriploid gibel carp by editing two duplicated runx2b homeologs. Aquaculture, 2023, 567: 7393. https://doi.org/10.1016/j.aquaculture.2023.739300.

[5]     Gong GR, Xiong Y, Xiao S, Li XY, Huang PP, Liao QH, Han Q, Lin Q, Dan C, Zhou L, Ren F, Zhou Q, Gui JF*, Mei J*.  Origin and chromatin remodeling of young X/Y sex chromosomes in catfish with sexual plasticity. National Science Review, 2023, 10(2): nwac239. https://doi.org/10.1093/nsr/nwac239.

[6]     Yu P, Wang Y, Li Z, Jin H, Li LL, Han X, Wang ZW, Yang XL, Li XY, Zhang XJ, Zhou L*, Gui JF*. Causal gene identification and desirable trait recreation in goldfish. Science China Life Sciences, 2022, 65(12): 2341-2353. https://doi.org/10.1007/s11427-022-2194-7.

[7]     Lu M, Li Z, Zhu ZY, Peng F, Wang Y, Li XY, Wang ZW, Zhang XJ, Zhou L*, Gui JF*. Changes in ploidy drive reproduction transition and genomic diversity in a polyploid fish complex. Molecular Biology and Evolution, 2022, 39(9): msac 188. https://doi.org/10.1093/molbev/msac188.

[8]     Wang Y, Li XY, Xu WJ, Wang K, Wu B, Xu M, Chen Y, Miao LJ, Wang ZW, Li Z, Zhang XJ, Yin Z, Zhou BT, Yang YL, Zhu CL, Hu ML, Zheng JM, Feng CG, Qiu Q, Tian LT, Lu M, Peng F, Lu WJ, Tong JF, Tong JG, Fu BD, Yu P, Ding M, Gan RH, Zhang QQ, Jian JB, Zhang C, He WM, Yang W, Zhao ZC, Zhang QQ, Gao Q, Xu JY, Bai MZ, Zhang YP, Yang HM, Fang XD*, Wang W*, Zhou L*, Gui JF*. 2022. Comparative genome anatomy reveals evolutionary insights into a unique amphitriploid fish. Nature Ecology & Evolution, 2022, 6, 1354-1366. https://doi.org/10.1038/s41559-022-01813-z.

[9]     Lu LF, Jiang JY, Du WX, Wang XL, Li ZC, Zhou XY, Zhang C, Mou CY, Chen DD, Li Z, Zhou L, Gui JF, Li XY*, Li S*. 2022. Fish female-biased gene cyp19a1a leads to female antiviral response attenuation between sexes by autophagic degradation of MITA. PLOS Pathogens, 18: e1010626. https://doi.org/10.1371/journal.ppat.1010626.

[10]  Wang MT, Li Z, Ding M, Yao TZ, Yang S, Zhang XJ, Miao C, Du WX, Shi Q, Li S, Mei J, Wang Y, Wang ZW, Zhou L, Li XY*, Gui JF*. Two duplicated gsdf homeologs cooperatively regulate male differentiation by inhibiting cyp19a1a transcription in a hexaploid fish. PLOS Genetics, 2022, 18(6): e1010288. https://doi.org/10.1371/journal.pgen.1010288.