PI: Prof. Jie Mei (jmei@ihb.ac.cn)

General Introduction

We are mainly engaged in the research of domestication and molecular design breeding of precious and high-quality fish, with the main research object of the yellow catfish, which has no intermuscular bones and tender meat. We have systematically carried out the genetic basis and biotechnology manipulation research on the sex determination and important economic traits of fish, and established a fish genetic breeding research system integrating "cutting-edge basic research, scientific and technological innovation in key breeding technology, and studies on creation of high-yield and high-quality new varieties". We have cultivated the new aquatic varieties of yellow catfish "All-male No. 2" and the hybrid yellow catfish "Huangyou No. 1".  

Representative publications

Gong G, Xiong Y, Xiao S, Li X, Huang P, Liao Q, Han Q, Lin Q, Dan C, Zhou L, Ren F, Zhou Q, Gui JF*, Mei J*. Origin and chromatin remodelling of young X/Y sex chromosomes in catfish with sexual plasticity. National Science Review, 2023, 10(2):nwac239.  

Ren F, Miao R, Xiao R*, Mei J*. m⁶A reader Igf2bp3 enables germ plasm assembly by m⁶A-dependent regulation of gene expression in zebrafish. Science Bulletin, 2021, 66(11): 1119-1128.  

Xiong S, Tian J, Ge S, Li Z, Long Z, Guo W, Huang P, He Y, Xiao T, Gui JF, Mei J*. The microRNA-200 cluster on chromosome 23 is required for oocyte maturation and ovulation in zebrafish. Biology of Reproduction. 2020, 103(4):769-778.  

Ren F, Lin Q, Gong G, Du X, Dan H, Qin W, Miao R, Xiong Y, Xiao R, Li X, Gui JF, Mei J*. Igf2bp3 maintains maternal RNA stability and ensures early embryo development in zebrafish. Communications Biology, 2020, 3(1):94.  

Xiong Y, Wang S, Gui JF, Mei J*. Artificially induced sex-reversal leads to transition from genetic to temperature-dependent sex determination in fish species. Science China Life Science, 2020, 63(1):157-159.  

Mei J, Gui J-F.《Sex Control in Aquaculture》, WILEY Blackwell, Chapter 24, “Sexual Size Dimorphism, Sex Determination, and Sex Control in Yellow Catfish”，2019 

Gong G, Dan C, Xiao S, Guo W, Huang P, Xiong Y, Wu J, He Y, Zhang J, Li X, Chen N, Gui JF*, Mei J*. Chromosomal-level assembly of yellow catfish genome using third-generation DNA sequencing and Hi-C analysis. GigaScience, 2018, 7(11): giy120.  

Dan C, Lin Q, Gong G, Yang T, Xiong S, Xiong Y, Huang P, Gui JF*, Mei J*. A novel PDZ domain-containing gene is essential for male sex differentiation and maintenance in yellow catfish (Pelteobagrus fulvidraco). Science Bulletin, 2018, 63: 1420-1430.  

Xiong S, Ma W, Jing J, Zhang J, Dan C, Gui JF*, Mei J*. An miR-200 Cluster on Chromosome 23 Regulates Sperm Motility in Zebrafish. Endocrinology, 2018, 159(5):1982-1991.  

Lin Q, Mei J*, Li Z, Zhang X, Zhou L, Gui JF*. Distinct and Cooperative Roles of amh and dmrt1 in Self-Renewal and Differentiation of Male Germ Cells in Zebrafish. Genetics, 2017, 207(3):1007-1022.  

Mei J, Gui JF*. Genetic basis and biotechnological manipulation of sexual dimorphism and sex determination in fish. Sci China Life Sci, 2015, 58(2):124-36.