PI: Shun Li (bob@ihb.ac.cn)

Research Group Members: Long-Feng Lu (Associate Professor), Dan-Dan Chen (Laboratory Technician), Zhuo-Cong Li (Special Research Assistant), Can Zhang (Special Research Assistant), and 8 undergraduate students.

Research Group Introduction:

This research group has long been engaged in the development of antiviral drugs for fish, the pathogenesis of fish viruses and the antiviral immune response in fish. The research group has led talent projects such as the Strategic Priority Research Program of the Chinese Academy of Sciences, and National Excellent Youth Science Fund, and National Natural Science Foundation of China, and Youth Innovation Promotion Association, and National Key Research and Development Program of China. We have published many papers in PLoS Pathogens, Journal of Immunology, Journal of Virology and other international journals, and have been recommended by Journal of Immunology for 4 times. We have also transformed a project of anti-viral disease technology in fish (RMB 1 million). 

Representative achievements in recent years:　 

Application of metal ions in the preparation of drugs against aquatic viral infections, RMB 1 million. 

Articles for publication: 

1. Long-Feng Lu^#, et al., Shun Li, Fish female-biased gene cyp19a1a leads to female antiviral response attenuation between sexes by autophagic degradation of MITA, PLoS Pathogens, 2022, 18:e1010626. 

2. Long-Feng Lu, et al., Shun Li, A novel role of Zebrafish TMEM33 in negative regulation of interferon production by two distinct mechanisms, PLoS Pathogens, 2021, 17:e1009317. 

3. Shun Li^#, et al., Spring viraemia of carp virus modulates p53 expression using two distinct mechanisms, PLoS Pathogens, 2019, 15:e1007695. 

4. Xue-Li Wang, et al., Long-Feng Lu^#, Shun Li^#, SVCV N Protein Negatively Regulates Interferon Induction Through Autophagy-Lysosome-Dependent Degradation of STING, Journal of Immunology, 2023, 210(1):72-81. 

5. Dan-Dan Chen, et al., Shun Li, Zebrafish Uba1 degrades IRF3 through K48-linked ubiquitination to inhibit IFN production, Journal of Immunology, 2021, 207:512-522. 

6. Dan-Dan Chen, et al., Shun Li, Zebrafish CERKL Enhances Host TBK1 Stability and Simultaneously Degrades Viral Protein via Ubiquitination Modulation. Journal of Immunology, 2022, 208:2196-2206. 

7. Long-Feng Lu, et al., Shun Li, Zebra？sh RBM47 promotes lysosome-dependent degradation of MAVS to inhibit IFN induction, Journal of Immunology, 2020, 205(7):1819-1829. 

8. Shun Li^#, Long-Feng Lu^#, et al., Zebrafish MVP recruits and degrades TBK1 to suppress IFN production, Journal of Immunology, 2019, 202:559-566. 

9. Long-Feng Lu^#, Shun Li^#, et al., Spring viremia of carp virus N protein suppresses fish IFNφ1 production by targeting the mitochondrial antiviral signaling protein, Journal of Immunology, 2016, 196:3744-3753. 

10. Shun Li, et al., IFN regulatory factor 10 is a negative regulator of the IFN responses in fish, Journal of Immunology, 2014, 193:1100-1109.  

11. Long-Feng Lu, et al., Shun Li, Zebrafish TMEM47 is an effective blocker of IFN production during RNA and DNA virus infection, Journal of Virology, 2023, (Accepted). 

12. Can Zhang, et al., Feng Ge^#, Shun Li^#, Zebrafish MAP2K7 Simultaneously Enhances Host IRF7 Stability and Degrades Spring Viremia of Carp Virus P Protein via Ubiquitination Pathway, Journal of Virology, 2023, 97(7):e0053223. 

13. Long-Feng Lu, et al., Shun Li, Zebrafish RPZ5 degrades the phosphorylated IRF7 to repress interferon production, Journal of Virology, 2019, 93(21):e01272-19. 

14. Shun Li, et al., The P protein of spring viremia of carp virus negatively regulates the fish interferon response by inhibiting the kinase activity of TANK-binding kinase 1, Journal of Virology, 2016, 90:10728-10737.