PI: Prof. CHANG Mingxian, PhD   

Team members:  

Professor and Dr., CHANG Mingxian; 

Associated Professor and Dr., Jie Zhang; 

Assistant Professor and Dr., WU Xiaoman   

Contact Us:  

Tel: +86-27-68780760 

Email: mingxianchang@ihb.ac.cn   

General Introduction:  

Research Group of Fish Comparative Immunology and Healthy Aquaculture has broad interest in fish immunology, molecular mechanisms of host-pathogen interactions, innate immune responses against pathogen infection, the mechanisms of pathogen clearance by innate immune receptors, the occurrence and development mechanisms of aquatic economic animal diseases.     

This group has published over 100 articles in reputable journals such as Reviews in Aquaculture、PLOS Pathogens、Communications Biology、Frontiers in Immunology、Immunology、Journal of Virology、Journal of Immunology、Ecological Indicators、Environmental Microbiology、Aquaculture、Cell Res、Protein Cell. They are currently undertaking research projects from the National Natural Science Foundation of China, the National Key Research and Development Program of China, “Agricultural Biological Breeding-2030” major project, and the Strategic Priority Program of Chinese Academy of Science etc.     

On-going Researches:  

* Disease-resistance breeding via genome editing 

* Functional comparisons of innate immune signaling pathways in vertebrates  

* Immune-evading mechanisms of pathogens  

* The effects of interaction among metabolism, immunity and pathogen on the occurrence of aquatic economic animal diseases   

Selective publications (*Corresponding author) 

1.     Li PW, Zhang J, Chang MX*. Structure, function and immune evasion strategies of aquareoviruses,with focus on grass carp reovirus. Rev Aquac. 2024;16(1):410-432. 

2.     Fang H, Wu XM, Zheng SY, Chang MX*. Tripartite motif 2b (trim2b) restricts spring viremia of carp virus by degrading viral proteins and negative regulators NLRP12-like receptors. J Virol. 2024;98(6):e0015824. 

3.     Song YJ, Zhang J, Xu Z, Nie P, Chang MX*. Liver X Receptor LXRα Promotes Grass Carp Reovirus Infection by Attenuating IRF3-CBP Interaction and Inhibiting RLR Antiviral Signaling. J Immunol. 2023;211(6):1006-1019. 

4.     Song YJ, Zhang J, Xiao J, Feng H, Xu Z, Nie P, Chang MX*. Piscine Vitamin D Receptors Vdra/Vdrb in the Absence of Vitamin D Are Utilized by Grass Carp Reovirus for Promoting Viral Replication. Microbiol Spectr. 2023;11(4):e0128723.  

5.     Chang MX.* Emerging mechanisms and functions of inflammasome complexes in teleost fish. Front Immunol. 2023;14:1065181. 

6.     Zhang J, Chang MX*. TBK1 Isoform Inhibits Grass Carp Reovirus Infection by Targeting the Degradation of Viral Nonstructural Proteins NS80 and NS38. J Immunol. 2023;210(2):191-203. 

7.     Zhang J, Li P, Lu R, Ouyang S*, Chang MX*. Structural and functional analysis of the small GTPase ARF1 reveals a pivotal role of its GTP-binding domain in controlling of the generation of viral inclusion bodies and replication of grass carp reovirus. Front Immunol. 2022;13:956587. 

8.     Cao L, Fang H, Yan D, Wu XM, Zhang J, Chang MX*. CD44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response. Commun Biol. 2022;5(1):889. 

9.     Fang H, Yang YY, Wu XM, Zheng SY, Song YJ, Zhang J, Chang MX*. Effects and Molecular Regulation Mechanisms of Salinity Stress on the Health and Disease Resistance of Grass Carp. Front Immunol. 2022;13:917497. 

10. Yang YY, Zheng SY, Fang H, Wu XM, Zhang J, Chang MX*. Immunoprotective Effects of Two Histone H2A Variants in the Grass Carp Against Flavobacterium columnare Infection. Front Immunol. 2022;13:939464. 

11. Zhang J, Wu XM, Fang Q, Bi YH, Nie P, Chang MX*. Grass Carp Reovirus Nonstructural Proteins Avoid Host Antiviral Immune Response by Targeting the RLR Signaling Pathway. J Immunol. 2022;208(3):707-719. 

12. Xiong F, Cao L, Xiong J, Wu YF, Huang WS, Chang MX*. Time-resolved and multi-tissue RNAseq provides new insights on the immune responses of European eels following infection with Aeromonas hydrophila. Water Biology and Security. 2022,1: 100003. 

13. Wu XM, Fang H, Zhang J, Bi YH, Chang MX*. Histone H2A Nuclear/Cytoplasmic Trafficking Is Essential for Negative Regulation of Antiviral Immune Response and Lysosomal Degradation of TBK1 and IRF3. Front Immunol. 2021;12:771277. 

14. Cao L, Yan D, Xiao J, Feng H, Chang MX*. The Zebrafish Antiapoptotic Protein BIRC2 Promotes Edwardsiella piscicida Infection by Inhibiting Caspases and Accumulating p53 in a p53 Transcription-Dependent and -Independent Manner. Front Immunol. 2021;12:781680. 

15. Qi Z*, Yan D, Cao L, Xu Y, Chang M*. Zebrafish BID Exerts an Antibacterial Role by Negatively Regulating p53, but in a Caspase-8-Independent Manner. Front Immunol. 2021;12:707426. 

16. Chang MX*, Xiong F, Wu XM, Hu YW. The expanding and function of NLRC3 or NLRC3-like in teleost fish: Recent advances and novel insights. Dev Comp Immunol. 2021;114:103859. 

17. Wu X, Xiong F, Fang H, Zhang J, Chang M*. Crosstalks between NOD1 and Histone H2A Contribute to Host Defense against Streptococcus agalactiae Infection in Zebrafish. Antibiotics (Basel). 2021;10(7):861. 

18. Li P, Chang M*. Roles of PRR-Mediated Signaling Pathways in the Regulation of Oxidative Stress and Inflammatory Diseases. Int J Mol Sci. 2021;22(14):7688. 

19. Xiong F, Cao L, Wu XM, Chang MX*. The function of zebrafish gpbar1 in antiviral response and lipid metabolism. Dev Comp Immunol. 2021;116:103955. 

20. Wu XM^#, Zhang J^#, Li PW, Hu YW, Cao L, Ouyang S, Bi YH, Nie P, Chang MX*. NOD1 Promotes Antiviral Signaling by Binding Viral RNA and Regulating the Interaction of MDA5 and MAVS. J Immunol. 2020;204(8):2216-2231.  

21. Zhang J, Wu XM, Hu YW, Chang MX*. A Novel Transcript Isoform of TBK1 Negatively Regulates Type I IFN Production by Promoting Proteasomal Degradation of TBK1 and Lysosomal Degradation of IRF3. Front Immunol. 2020;11:580864.  

22. Chang MX*, Xiong F, Wu XM, Hu YW. The expanding and function of NLRC3 or NLRC3-like in teleost fish: Recent advances and novel insights. Dev Comp Immunol. 2020;114:103859.  

23. Chang MX*, Xiong F. Astaxanthin and its Effects in Inflammatory Responses and Inflammation-Associated Diseases: Recent Advances and Future Directions. Molecules. 2020;25(22):E5342.  

24. Xiong F, Cao L, Wu XM, Chang MX*. The function of zebrafish gpbar1 in antiviral response and lipid metabolism. Dev Comp Immunol. 2020;116:103955.  

25. Fang H, Wu XM, Hu YW, Song YJ, Zhang J, Chang MX. NLRC3-like 1 inhibits NOD1-RIPK2 pathway via targeting RIPK2. Dev Comp Immunol. 2020;112:103769.  

26. Xiong F, Xiong J, Wu YF, Cao L, Huang WS*, Chang MX*. Time-resolved RNA-seq provided a new understanding of intestinal immune response of European eel (Anguilla anguilla) following infection with Aeromonas hydrophila. Fish Shellfish Immunol. 2020;105:297-309.  

27. Nabi G, McLaughlin RW, Khan S, Hao Y, Chang MX. Pneumonia in endangered aquatic mammals and the need for developing low-coverage vaccination for their management and conservation. Anim Health Res Rev. 2020:1-9. 

28. 武小曼，方红，聂品，昌鸣先*. 鱼类组蛋白核苷酸的多态性及其在杀鱼爱德华氏菌感染中的作用. 水产学报, 2020, 44(0): 1？14.  

29. Zhang C, Zhang Q, Wang J, Tian J, Song Y, Xie H, Chang M, Nie P, Gao Q*, Zou J*. Transcriptomic responses of S100 family to bacterial and viral infection in zebrafish. Fish Shellfish Immunol. 2019;94:685-696.  

30. Wu XM, Cao L, Nie P, Chang MX*. Histone H2A cooperates with RIP2 to induce the expression of antibacterial genes and MHC related genes. Dev Comp Immunol. 2019;101:103455.  

31. Wu XM, Cao L, Hu YW, Chang MX*. Transcriptomic characterization of adult zebrafish infected with Streptococcus agalactiae. Fish Shellfish Immunol. 2019;94:355-372.  

32. Cao L, Wu XM, Nie P, Chang MX*. The negative regulation of piscine CD44c in viral and bacterial infection. Dev Comp Immunol. 2019;96:135-143.  

33. Rahman K, Khan SU, Fahad S*, Chang MX*, Abbas A, Khan WU, Rahman L, Haq ZU, Nabi G, Khan D. Nano-biotechnology: a new approach to treat and prevent malaria. Int J Nanomedicine. 2019;14:1401-1410.  

34. Zhang J, Guo H, Zhang F, Chen Q, Chang M*, Fang Q*. NS38 is required for aquareovirus replication via interaction with viral core proteins and host eIF3A. Virology. 2019;529:216-225.  

35. Zhen X, Zhou H, Ding W, Zhou B, Xu X, Per？ulija V, Chen CJ, Chang MX, Choudhary MI, Ouyang S*. Structural basis of AimP signaling molecule recognition by AimR in Spbeta group of bacteriophages. Protein Cell. 2019;10(2):131-136.  

36. Wu XM, Chen WQ, Hu YW, Cao L, Nie P, Chang MX*. RIP2 Is a Critical Regulator for NLRs Signaling and MHC Antigen Presentation but Not for MAPK and PI3K/Akt Pathways. Front Immunol. 2018;9:726.  

37. Cao L, Wu XM, Hu YW, Xue NN, Nie P, Chang MX*. The discrepancy function of NLRC5 isoforms in antiviral and antibacterial immune responses. Dev Comp Immunol. 2018;84:153-163.  

38. Hu YW, Zhang J, Wu XM, Cao L, Nie P, Chang MX*. TANK-Binding Kinase 1 (TBK1) Isoforms Negatively Regulate Type I Interferon Induction by Inhibiting TBK1-IRF3 Interaction and IRF3 Phosphorylation. Front Immunol. 2018;9:84.  

39. Zhang B, Ye W, Ye Y, Zhou H, Saeed AFUH, Chen J, Lin J, Per？ulija V, Chen Q, Chen CJ, Chang MX, Choudhary MI, Ouyang S*. Structural insights into Cas13b-guided CRISPR RNA maturation and recognition. Cell Res. 2018;28(12):1198-1201.  

40. Chang MX^#, Zou J^#, Nie P, Huang B, Yu Z, Collet B, Secombes CJ*. Intracellular interferons in fish: a unique means to combat viral infection. PLoS Pathog. 2013;9(11):e1003736.