PI：Prof. LUO Daji, PhD (luodaji@ihb.ac.cn)

Group Members: 

Dr. LIU Fei (Associated Prof.) 

Dr. ZHAO Yuanli  

Mr. OUYANG Gang (Lab Manager and Senior technician, Master’s Degree) 

4 Ph.D students, 6 Postgraduate students and 4 Joint Postgraduate students 

Research： 

Fish RNA biology research group (Luo Lab) has been focused on 3 major research areas: 

(1) RNA regulation mechanism during sex reversal in fish 

(2) Regulation of gene expression, alternative splicing, non-coding RNAs and other elements during sex determination and sex differentiation in fish 

(3) Gene engineering in fish genetic breeding 

We welcome talented and motivated postdocs and students to join force in addressing several fundamental questions in fish RNA biology and genetic breeding. 

Selected Publications in the past five years： 

1.     Li Y^#, Chen Z^#, Liu H^#, Li Q, Lin X, Ji S, Li R, Li S, Fan W, Zhao H, Zhu Z, Hu W*, Zhou Y*, Luo D*. (2021) ASER: Animal Sex Reversal Database. Genomics, Proteomics & Bioinformatics.19:873-881. (Cover story)  

2.     Han Y^#, Sun K^#, Yu S^#, Qin Y^#, Zhang Z, Luo J, Hu H, Dai L, Cui M, Jiang C, Liu F, Huang Y, Gao P, Chen X, Xin T, Ren X, Wu X, Song J, Wang Q, Tang Z, Chen J, Zhang H, Zhang X*, Liu M*, Luo D*. (2024) A Mettl16/m6A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells. The EMBO Journal. 43(10):1990-2014.  

3.     Yu S^#, Jiang T^#, Jia D, Han Y, Liu F, Huang Y, Qu Z, Zhao Y, Tu J, Lv Y, Li J, Hu X, Lu Z, Han S, Qin Y, Liu X, Xie S, Wang QK, Tang Z, Luo D*, Liu M*.  (2019) BCAS2 is essential for hematopoietic stem and progenitor cell maintenance during zebrafish embryogenesis. Blood. 133:805-815.  (Cover story)   

4.     Zhao Y^#, Duan M^#, Lin X^#, Li W, Liu H, Meng K, Liu F, Hu W, Luo D*. (2023) Molecular underpinnings underlying behaviors changes in the brain of juvenile common carp (Cyrinus carpio) in response to warming. Journal of Advanced Research. 10.1016/j.jare.2023.10.017. 

5.     Chen H, Luo D*. (2023) Application of haematology parameters for health management in fish farms. Reviews in Aquaculture. 15: 704-737. (Cover story)  

6.     Zhao Y^#, Chen Z^#, Hu M^#, Liu H, Zhao H, Huang Y, Jiang M, Li S, Li G, Zhu C*, Hu W*, Luo D*. (2024) Integrating Iso-seq and RNA-seq data for the reannotation of the greater amberjack genome. Scientific Data. 10.1038/S41597-024-03495-7.  

7.     Meng K, Lin X, Chen Y, Hu M, Hu W, Luo D*. (2023) Integrated analysis of the digestive tract bacterial community on individual growth in sibling generation of Swamp Eels (Monopterus albus). Aquaculture. 566 (1): 739228.  

8.     Liu F, Lin X, Meng K, Chen Y, Liu H, Zhao Y, Luo D*. (2023) Identification of potential indicators for testis quality in swamp eels (Monopterus albus) through metabolomics analysis. Water Biology and Security. 2(2): 100204.  

9.     Meng K, Lin X, Liu H, Chen H, Liu F, Xu Z, Sun Y, Luo D*. (2022) Gonadal bacterial community composition is associated with sex-specific differences in Swamp eels (Monopterus albus). Frontiers in Immunology. 13: 938326.   

10. Chen H, Zhao Y, Chen K, Wei Y, Luo H, Li Y, Liu F, Zhu Z, Hu W, Luo D*. (2022) Isolation, identification, and investigation of pathogenic bacteria from common carp (Cyprinus carpio) naturally infected with Plesiomonas shigelloides.  Frontiers in Immunology. 13: 872896. 

11. Zhao Y^#, Chen K^#, Liu F, Jiang M, Chen Z, Chen H, Song Y, Tao B, Cui X, Li Y, Zhu Z, Chen J*, Hu W*, Luo D*. (2022) Dynamic gene expression and alternative splicing events demonstrate co-regulation of testicular differentiation and maturation by the brain and gonad in Common Carp. Frontiers in Endocrinology. 12: 820463.  

12. Liu F, Qin Y, Huang Y, Gao P, Li J, Yu S, Jia D, Chen X, Lv Y, Tu J, Sun K, Han Y, Reilly J, Shu X, Lu Q, Tang Z, Xu C*, Luo D*, Liu M*. (2022) Rod genesis driven by mafba in an nrl knockout zebrafish model with altered photoreceptor composition and progressive retinal degeneration. PLOS Genetics. 18: e1009841.  

13. Chen H, Liu H, Li R, Lin X, Luo H, Ji S, Hu W, Luo D*. (2021) Blood cell identification and hematological analysis during natural sex reversal in rice field eel (Monopterus albus). Aquaculture. 538 (11): 736543.  

14. Luo D, Feng K, Zhu Z, Hu W*. (2019) Genrating gene knockout Oryzias Latipes and Rice Field eel using TALENs method. Methods in Molecular Biology. 1874:489-506.     

15. Zhou B^#, Li X^#,*, Luo D^#, Lim DH, Zhou Y, Fu XD^*. (2019) GRID-seq for comprehensive analysis of global RNA-Chromatin interactions. Nature Protocols. 14:2036-2068.   

16. Xiao R^#,*, Chen JY^#, Liang Z^#, Luo D, Chen G, Lu Z, Chen Y, Zhou B, Li H, Du X, Yang Y, San KM, Wei X, Liu W, Lecuyer E, Graveley BR, Yeo G, Burge CB, Zhang QM, Zhou Y, Fu XD*. (2019) Pervasive Chromatin-RNA binding protein interactions enable RNA-based regulation of transcription. Cell. 178:107-121.