Research Group of Environmental Toxicology
PI: Prof. ZHOU Bingsheng, PhD
Focused on the traditional and emerging persistent organic pollutants (POPs), the Research Group of Environmental Toxicology investigated the distribution and transformation in the environmental media, tried to reveal their toxicity and underlying mechanism on aquatic organism, and evaluated their potential risks to the aquatic ecology.
Specifically, they investigated the effects and underlying mechanism on the endocrine disruption, neurodevelopment and metabolism at individual, physiological, biochemical molecular and epigenetic levels after exposure to these POPs alone or combining with other coexisting chemicals, thus obtained more toxicity data for further risk assessment, and found out more sensitive biomarkers that may be suitable for early warning system.
They also investigated the distribution of some organic pollutants in the aquatic environment, and predicted their potential risks to the ecology using multi-level risk assessment methods basing on the determined concentrations. Their research results can provide theoretical basis and useful data for the risk assessment of traditional and emerging POPs, and also support for the decisions concerning ecological environment protection and sustainable development strategy. This group has developed good platforms for chemical analysis and toxicity tests, and formed a steadily developing and energetic research team.
1. Chunsheng Liu, Deng Jun., Yu Liqin., Ramesh M., Bingsheng Zhou* (2009). Endocrine disruption and reproductive impairment in zebrafish by exposure to 8:2 fluorotelomer alcohol. Aquatic Toxicology (in press).
2. Xiongjie Shi., Liu Chunsheng., Wu Guoqiao, Bingsheng Zhou* (2009). Waterborne exposure to PFOS causes disruption of the hypothalamus-pituitary-thyroid axis in zebrafish larvae. Chemosphere (in press).
3. Xiongjie Shi, Leo W. Y. Yeung, Paul K. S. Lam, Rudolf S. S. Wu, Bingsheng Zhou* (2009). Protein profiles in zebrafish (Danio rerio) embryos exposed to PFOS. Toxicological Sciences 110, 334 - 340 2.
4. Chunsheng Liu, Liqin Yu, Jun Deng, Paul K. S. Lam, Rudolf S. S. Wu, Bingsheng Zhou* (2009). Waterborne exposure to fluorotelomer alcohol 6:2 FTOH alters plasma sex hormone and gene transcription in the hypothalamic–pituitary–gonadal (HPG) axis of zebrafish. Aquatic Toxicology 93, 131-137.
5. Jun Deng, Liqin Yu, Chunsheng Liu, Ke Yu, Xiongjie Shi, Leo WY Yeung, Paul KS Lam, Rudolf SS Wu, Bingsheng Zhou*(2009). HBCD-induced developmental toxicity and apoptosis in zebrafish embryos. Aquatic Toxicology 93, 29-36.
6. Yongbing Du, Xiongjie Shi, Chunsheng Liu, Ke Yu, Bingsheng Zhou* (2009). Chronic effects of water-borne PFOS exposure on growth, survival and hepatotoxicity in zebrafish: A partial life-cycle test. Chemosphere 74, 723-729.
7. Ke Yu, Yuhe He, Leo W.Y. Yeung, Paul KS Lam, Rudolf SS Wu, Bingsheng
Zhou* (2008). DE-71-induced apoptosis involving intracellular calcium and the Bax-mitochondria-caspase protease pathway in human neuroblastoma cells in vitro. Toxicological Sciences 104, 341-351.
8. Xiongjie Shi, Yongbing Du, Paul KS Lam, Rudolf SS Wu, Bingsheng Zhou* (2008). Developmental toxicity and alteration of gene expression in zebrafish embryos exposed to PFOS. Toxicology & Applied Pharmacology 230, 23-32.
9. Chunsheng Liu, Yongbing Du, Bingsheng Zhou* (2007). Evaluation of estrogenic activities and mechanism of action of perfluorinated chemicals determined by vitellogenin induction in primary cultured tilapia hepatocytes. Aquatic Toxicology 85, 267-277.
10. Chunsheng Liu, Ke Yu, Xiongjie Shi, Jingxian Wang, Paul K.S. Lam, Rudolf S.S. Wu and Bingsheng Zhou* (2007). Induction of oxidative stress and apoptosis by PFOS and PFOA in primary cultured hepatocytes of freshwater tilapia (Oreochromis niloticus). Aquatic Toxicology 82,135-143.
11. Ling Ding, Margaret B. Murphy, Henry Y.H. He, Yan Xu, Leo W.Y. Yeung, Jingxian Wang, Bingsheng Zhou*, Paul K.S. Lam, Rudolf S.S. Wu and John P. Giesy (2007). Effects of brominated flame retardants and brominated dioxins on steroidgenesis in H295R human adrenocortical carcinoma cell line. Environmental Toxicology & Chemistry 26, 764-772.
12. Bingsheng Zhou*, Chunsheng Liu, Jingxian Wang, Paul K.S. Lam, Rudolf S.S. Wu (2006). Primary cultured cells as sensitive in vitro model for assessment of toxicants-comparison to hepatocytes and gill epithelia. Aquatic Toxicology 80, 109-118.