Yonghua SUN

Faculty

Name：	Yonghua SUN
Academic Title：	Professor
Education：	Ph.D.
Phone：	86-27-68780235
E-mail：	yhsun@ihb.ac.cn

Resume：

Education:

09/2006-03/2008: FFCSA (La Fondation franco-chinoise pour la science et ses applications) post-doctoral research associate, IGBMC, France (Mentor: Profs. Bernard Thisse and Christine Thisse)

02/2005-08/2006: Post-doctoral research associate, IGBMC, France (Mentor: Profs. Bernard Thisse and Christine Thisse)

09/1997-10/2002: Ph.D. study at Institute of Hydrobiology, Chinese Academy of Sciences, China (Mentor: Prof. Zuoyan Zhu)

09/1993-07/1997: BSc study at the College of Life Science, Wuhan University, China

Research Experience:

12/2010-present: Professor, Institute of Hydrobiology, Chinese Academy of Sciences, China

11/2011-present: Director, National Zebrafish Resource Center, Institute of Hydrobiology, Chinese Academy of Sciences, China

01/2005-11/2010: Associate Professor, Institute of Hydrobiology, Chinese Academy of Sciences, China

11/2009-12/2009: Visiting Associate Professor, Department of Cell Biology, University of Virginia, US

07/2002-12/2004: Assistant Professor, Institute of Hydrobiology, Chinese Academy of Sciences, China

Selected Publications：

　　1) Liu, L., Pan, L., Li, K., Zhang, Y., Zhu, Z. and Sun, Y.H.* (2016). Zebrafish Health Conditions in the China Zebrafish Resource Center and 20 Major Chinese Zebrafish Laboratories. Zebrafish 13 Suppl 1, S8-S18.

　　2) He, M.-D., Zhang, F.-H., Wang, H.-L., Wang, H.-P., Zhu, Z.-Y. and Sun, Y.-H.* (2015). Efficient ligase 3-dependent microhomology-mediated end joining repair of DNA double-strand breaks in zebrafish embryos. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 780, 86-96.

　　3) Pang, S.-C., Wang, H.-P., Zhu, Z.-Y. and Sun, Y.-H*. (2015). Transcriptional Activity and DNA Methylation Dynamics of the Gal4/UAS System in Zebrafish. Marine Biotechnology, 17(5):593-603.

　　4) Xie, X., Pan, L. and Sun, Y.* (2015). Growing with the world: rapid development of the zebrafish research in China and the China Zebrafish Resource Center. Sci China Life Sci 58, 396-399.

　　5) Ye, D., Zhu, Z. and Sun, Y.* (2015). Fish genome manipulation and directional breeding. Sci China Life Sci 58, 170-177.

　　6) Wei Z-Q, Xiong F, He M-D, Wang H-P, Zhu Z-Y, Sun Y-H*. (2015) Suppression of Ligase 4 or Xrcc6 activities enhances the DNA homologous recombination efficiency in zebrafish primordial germ cells. Acta Hydrobiol. 39(2):339-48.

　　7) Wei, C. Y., Wang, H. P., Zhu, Z. Y. and Sun, Y. H.* (2014). Transcriptional factors Smad1 and Smad9 act redundantly to mediate zebrafish ventral specification downstream of smad5. The Journal of Biological Chemistry 289, 6604-6618.

　　8) Sun, Y. H.* and Zhu, Z. Y. (2014). Cross-species cloning: influence of cytoplasmic factors on development. J Physiol 592, 2375-2379.

　　9) Lu, F.-I., Sun, Y.-H.*, Wei, C.-Y., Thisse, C. and Thisse, B. (2014). Tissue-specific derepression of TCF/LEF controls the activity of the Wnt/β-catenin pathway. Nat Commun 5, 5368. (*co-first author)

　　10) Pang, S. C., Wang, H. P., Li, K. Y., Zhu, Z. Y., Kang, J. X. and Sun, Y. H.* (2014). Double Transgenesis of Humanized fat1 and fat2 Genes Promotes Omega-3 Polyunsaturated Fatty Acids Synthesis in a Zebrafish Model. Mar Biotechnol (NY) 16, 580-593.

　　11) Xiong, F., Wei, Z. Q., Zhu, Z. Y. and Sun, Y. H.* (2013). Targeted Expression in Zebrafish Primordial Germ Cells by Cre/loxP and Gal4/UAS Systems. Mar Biotechnol (NY) 15, 526-539.

　　12) Liu, C.-W., Xiong, F., Jia, H.-Z., Wang, X.-L., Cheng, H., Sun, Y.-H.*, Zhang, X.-Z., Zhuo, R.-X. and Feng, J. (2013a). Graphene-Based Anticancer Nanosystem and Its Biosafety Evaluation Using a Zebrafish Model. Biomacromolecules 14, 358-366.

　　13) Wang, Y.-W., Wei, C.-Y., Dai, H.-P., Zhu, Z.-Y. and Sun, Y.-H.* (2013). Subtractive phage display technology identifies zebrafish marcksb that is required for gastrulation. Gene 521, 69-77.

　　14) Ishtiaq Ahmed, A. S., Xiong, F., Pang, S. C., He, M. D., Waters, M. J., Zhu, Z. Y. and Sun, Y. H.* (2011). Activation of GH signaling and GH-independent stimulation of growth in zebrafish by introduction of a constitutively activated GHR construct. Transgenic Res 20, 557-567.

　　15) Chen, C.-H., Sun, Y.-H.*, Pei, D.-S. and Zhu, Z.-Y. (2009). Comparative Expression of Zebrafish Lats1 and Lats2 and Their Implication in Gastrulation Movements. Developmental Dynamics 238, 2850-2859.

　　16) Liu, Y., Bourgeois, C. F., Pang, S., Kudla, M., Dreumont, N., Kister, L., Sun, Y.-H., Stevenin, J. and Elliott, D. J. (2009). The Germ Cell Nuclear Proteins hnRNP G-T and RBMY Activate a Testis-Specific Exon. PLoS Genetics 5 (11): e1000707.

　　17)Liu, J., Sun, Y. H.*, Wang, Y. W., Wang, N., Pei, D. S., Wang, Y. P., Hu, W. and Zhu, Z. Y. (2008). Identification of differential transcript profiles between mutual crossbred embryos of zebrafish (Danio rerio) and Chinese rare minnow (Gobiocypris rarus) by cDNA-AFLP. Theriogenology 70, 1525-1535.

　　18) Pei, D. S., Sun, Y. H.*, Chen, C. H., Chen, S. P., Wang, Y. P., Hu, W. and Zhu, Z. Y. (2008). Identification and characterization of a novel gene differentially expressed in zebrafish cross-subfamily cloned embryos. BMC Dev Biol 8, 29.

　　19) Pei, D. S., Sun, Y. H.*, Chen, S. P., Wang, Y. P., Hu, W. and Zhu, Z. Y. (2007). Identification of differentially expressed genes from the cross-subfamily cloned embryos derived from zebrafish nuclei and rare minnow enucleated eggs. Theriogenology 68, 1282-1291.

　　20)Pei, D. S., Sun, Y. H.*, Chen, S. P., Wang, Y. P., Hu, W. and Zhu, Z. Y. (2007). Zebrafish GAPDH can be used as a reference gene for expression analysis in cross-subfamily cloned embryos. Anal Biochem 363, 291-293.

　　21)Wang, N., Sun, Y. H.*, Liu, J., Wang, Y. P. and Zhu, Z. Y. (2007). Molecular characterization of common carp (Cyprinus carpio) Sonic Hedgehog and discovery of its maternal expression. Development Genes and Evolution 217, 299-305.

　　22)Wang, N., Sun, Y. H.*, Liu, J., Wu, G., Su, J. G., Wang, Y. P. and Zhu, Z. Y. (2007). Knock down of gfp and no tail expression in zebrafish embryo by in vivo-transcribed short hairpin RNA with T7 plasmid system. Journal of Biomedical Science 14, 767-776.

　　23)Liu, J., Sun, Y. H.*, Wang, N., Wang, Y. P. and Zhu, Z. Y. (2006). Upstream regulatory region of zebrafish lunatic fringe: Isolation and promoter analysis. Marine Biotechnology 8, 357-365.

　　24)Sun, Y. H., Chen, S. P., Wang, Y. P., Hu, W. and Zhu, Z. Y. (2005). Cytoplasmic impact on cross-genus cloned fish derived from transgenic common carp (Cyprinus carpio) nuclei and goldfish (Carassius auratus) enucleated eggs. Biol Reprod 72, 510-515.

　　25)Liu, W. Y., Wang, Y., Sun, Y. H.*, Wang, Y. P., Chen, S. P. and Zhu, Z. Y. (2005). Efficient RNA interference in zebrafish embryos using siRNA synthesized with SP6 RNA polymerase. Development Growth & Differentiation 47, 323-331.

　　26)Wu, B., Sun, Y. H.*, Wang, Y. W., Wang, Y. P. and Zhu, Z. Y. (2005). Characterization of transgene integration pattern in F4 hGH-transgenic common carp (Cyprinus carpio L.). Cell Research 15, 447-454. (* co-first author)

　　27) Wu, B., Sun, Y. H.*, Wang, Y. P., Wang, Y. W. and Zhu, Z. Y. (2004). Sequences of transgene insertion sites in transgenic F4 common carp. Transgenic Research 13, 95-96. (* co-first author)

　　28)Wu, G., Sun, Y. H.* and Zhu, Z. Y. (2003). Growth hormone gene transfer in common carp. Aquatic Living Resources 16, 416-420. (* co-first author)

　　29)Sun, Y., Chen, S., Wang, Y. and Zhu, Z. (2000). The onset of foreign gene transcription in nuclear-transferred embryos of fish. Sci China C Life Sci 43, 597-605.

　　30) Zhu, Z. Y. and Sun, Y. H. (2000). Embryonic and genetic manipulation in fish. Cell Research 10, 17-27.

　　31) 张峰华, 王厚鹏, 黄思雨, 熊凤, 朱作言,孙永华* (2016). 两种密码子优化的 Cas9 编码基因在斑马鱼胚胎中基因敲除效率的比较. 遗传 38, 144-154.