Education:   

1999:  Ph.D., Department of Biological Sciences, National University of Singapore， Singapore.  

1989:  M.Sc., Institute of Hydrobiology, Chinese Academy of Sciences, China.   

1986:  B.S,  Department of Biology, Wuhan University, China.   

Research Experience: 

2005.5-present: Principal investigator, Institute of Hydrobiology, Chinese Academy of Sciences. Wuhan, China .  

1989.7-1994.8:  assistant Professor, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China .   

Postdoctoral training 

2003.5-2005.4:  Postdoctoral research fellow at Molecular Cardiology Research Center, Department of Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA. USA 

2002.9-2003.5:  Research associate at Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH. USA 

2000.3-2002.8:  Research associate at Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH. USA 

1999.7-2000.2   Post-doctoral fellow at Medical research center, IUPUI, Indianapolis, IN, USA. 

1.        Peng, X., Shang, G., Wang, W., Chen, X., Lou, Q., Zhai, G., Li, D., Du, Z., Ye, Y., Jin, X., He, J., Zhang, Y., Yin, Z.* . 2017. Fatty Acid Oxidation in Zebrafish Adipose Tissue Is Promoted by 1α,25 (OH) ₂ D ₃. Cell Reports. 19:1444-1455.

2.        Zhai, G., Song, J., Shu, T., Yan, J., Jin, X., He, J., Yin, Z*. 2017. LRH-1 senses signaling from phosphatidylcholine to regulate the expansion growth of digestive organs via synergy with Wnt/β-catenin signaling in zebrafish. Journal of Genetics and Genomics (In press)

3.        Dai, X., Shu, Y., Lou, Q., Tian, Q., Zhai, G., Song, J., Lu, S., Yu, H., He, J., Yin, Z. * 2017. Tdrd12 Is Essential for Germ Cell Development Maintenance in Zebrafish. International Journal of Molecular Sciences. 18(6), 1127;

4.        Yang, J., Li Z., Gan, X., Zhai, G., Gao, J., Xiong, C., Qiu, X., Wang, X., Yin, Z.*, Zheng, F.* 2016.  Deletion of Pr130 Interrupts Cardiac Development in Zebrafish. International Journal of Molecular Sciences. 17(11), 1746.

5.        Gao Y, Dai Z, Shi C, Zhai G, Jin X, He J, Lou Q and Yin Z* 2016. Depletion of Myostatin b Promotes somatic growth and lipid Metabolism in Zebrafsh.  Frontier in Endocrinology. 7:88.

6.        Zhai, G., Shu, T., Xia, Y., Jin, X., He, J., Yin Z. * 2016. Androgen signaling regulates the transcription of anti-Müllerian hormone via synergy with SRY-Related Protein SOX9A.  Science Bulletin. 62 (3), 197-203.

7.        Shu, Y., Lou, Q., Dai, Z., Dai, X., He, J., Hu, W.*, Yin, Z*. 2016. The basal function of teleost prolactin as a key regulator on ion uptake identified with zebrafish knockout models  Scientific Reports. 6, Article number: 18597

8.        Dai X, Jin X, Chen X, He J, Yin Z*. 2015.  Sufficient numbers of early germ cells are essential for female sex development in zebrafish. PLoS One. 2015 Feb 13;10(2):e0117824.

9.        Dai X, Zhang W, Zhuo Z, He J, Yin Z*. 2015. Neuroendocrine regulation of somatic growth in fishes (Review). Science in China Life Science. 58(2):137-47. Review.

10.    Cheng,X., Chen,X., Li, D., Jin, X., He, J., Yin Z*. 2015. Effects of metronidazole on proopiomelanocortin a gene expression in zebrafish. General and Comparative Endocrinology. 214：87-94.

11.    Cheng, X., Chen, X., Jin, X., He, J., Yin, Z*. 2014. Generation and Characterization of Gsuα:EGFP Transgenic Zebrafish for Evaluating Endocrine-Disrupting Effects. Toxicology and Applied Pharmacology. 278(1): 78-84.  

12.    He, W., Dai, X., Chen, X., He, J., Yin, Z*. 2014. Zebrafish Pituitary Gene Expression Before and After Sexual Maturation. Journal of Endocrinology. 221(3):429-440.  

13.    Li, D., Lou, Q., Zhai, G., Peng, X., Cheng, X., Dai, X., Zhuo, Z., Shang, G., Jin, X., Chen, X., Han, D., He, J., Yin, Z.* 2014. Hyperplasia and Cellularity Changes in IGF-1-Overexpressing Skeletal Muscle of Crucian Carp. Endocrinology. 155 (6)：2199-2212.  

14.    Zhai, G., Gu, Q., He, J., Lou, Q., Chen, X., Jin, X., Bi, E.*, Yin, Z.* 2014. Sept6 is required for ciliogenesis in Kupffer's vesicle, pronephros and neural tube during early embryonic development. Molecular and Cellular Biology. 34(7): 1310-1321.  

15.    Mei Y, Yin N, Jin X, He J, Yin Z* 2013. The regulatory role of the adrenergic agonists phenylephrine and isoproterenol on fetal hemoglobin expression and erythroid differentiation. Endocrinology. 154(12):4640-9.

16.    Chen D, Li L, Tu X, Yin Z*, Wang Q*. 2013. Functional characterization of Klippel-Trenaunay syndrome gene AGGF1 identifies a novel angiogenic signaling pathway for specification of vein differentiation and angiogenesis during embryogenesis. Human Molecular Genetics. 22(5):963-76.

17.    Cui X, Zhang, J., Du, R., Wang, L., Archacki, S., Zhang, Y., Yuan, M., Ke, T., Li, H., Li, D., Li, C., Li, DW., Tang, Z., Yin, Z*., Liu, M*. HSF4 is involved in DNA damage repair through regulation of Rad51. Biochimica et Biophysica Acta-Molecular Basis of Diseases. 1822(8):1308-15.

18.    Ji C., Jin X., He J.,Yin, Z*. 2012. Use of TSHbeta:EGFP transgenic zebrafish as a rapid in vivo model for assessing thyroid-disrupting chemicals. Toxicology and Applied Pharmacology. 262(2):149-155

19.    Jiang N., Jin X., He J., Yin Z*. 2012 The Roles of follistatin 1 in Regulation of Zebrafish Fecundity and Sexual Differentiation. Biology of Reproduction. 87 (3) 54, 1-8.

20.    Chen X., Lou Q., He J. & Yin Z*. 2012. Role of Zebrafish Lbx2 in Embryonic Lateral Line Development. PLoS ONE 6(12): e29515.

21.    Lou Q., He J., Hu L., Yin Z*. 2012. Role of lbx2 in the noncanonical Wnt signaling pathway for convergence and extension movements and hypaxial myogenesis in zebrafish. Biochimica et Biophysica Acta - Molecular Cell Research. 823(5):1024-32.

22.    Li X., He J., Hu W & Yin Z * 2009. The essential role of endogenous ghrelin in growth hormone expression during zebrafish adenohypophysis development. Endocrinology. 150(6):2767-74.

23.    Ma L., Li D., Wang J., He J & Yin Z * 2009. Effects of Adrenergic Agonists on the Extrahepatic Expression of Vitellogenin Ao1 in Heart and Brain of the Chinese Rare Minnow (Gobiocypris rarus). Aquatic Toxicology. 91 (1): 19-25.

24.    Trivedi CM*, Luo Y*, Yin Z*, Zhang M, Zhu W, Wang T, Floss T, Goettlicher M, Noppinger PR, Wurst W, Ferrari VA, Abrams CS, Gruber PJ, Epstein JA. 2007. HDAC2 regulates the cardiac fetal gene program and hypertrophic responsiveness by modulating GSK3？. Nature Medicine. 13(3): 324-331. (*Equal first author).

25.    Yin, Z.*, Gonzales, L*., Kolla, V., Rath, N., Zhang, Y., Lu, MM., Kimura, S., Ballard, PL., Beers, MF., Epstein, JA. & Morrisey, EE. 2006. Hop functions downstream of Nkx2.1 and Gata6 to mediate HDAC-dependent negative regulation of pulmonary gene expression. American Journal of Physiology, Lung Cellular and Molecular Physiology. 291：L191-199. (*Equal first author)

26.    Yin, Z., Jeni Haynie, Bryan R. Williams and Yu-Chung Yang. 2003. C114 is a novel IL-11-inducible nuclear dsRNA-binding protein that inhibits Protein Kinase R. Journal of Biological Chemistry. 278, 22838-22845.

27.    Yin, Z. Haynie, J., Yang, X.,. Han, B., Kiatchoosakun, S., Restivo, J., Yuan, S., Prabhakar, N. R., Herrup, K., Conlon, R. A., Hoit, B. D., Watanabe, M and Yu-Chung Yang. 2002. The essential role of Cited2, a negative regulator hif-1 in heart development and neurulation. Proceedings of National Academy of Sciences of the United States of America. 99, 10488-10493.

Last updated on June 20^th, 2017