Research
| Title： | Molecular programming of the hepatic lipid metabolism via a parental high carbohydrate and low protein diet in rainbow trout |
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| First author： | Callet, Therese; Li, Hongyan; Heraud, Cecile; Larroquet, Laurence; Lanuque, Anthony; Sandres, Franck; Terrier, Frederic; Surget, Anne; Corraze, Genevieve; Panserat, Stephane; Marandel, Lucie |
| Journal： | ANIMAL |
| Years： | 2022 |
| DOI： | 10.1016/j.animal.2022.100670 |
| Abstract： | It is now recognised that parental diets could alter their offspring metabolism, concept known as nutri-tional programming. For agronomic purposes, it has been previously proposed that programming could be employed as a strategy to prepare individual for future nutritional challenges. Concerning cultured fish that belong to high trophic level, plant-derived carbohydrates are a possible substitute for the traditional protein-rich fishmeal in broodstock diet, lowering thus the dietary protein-to-carbohydrate ratio (HC/LP nutrition). However, in mammals, numerous studies have previously demonstrated that parental HC/LP nutrition negatively affects their offspring in the long term. Therefore, the question of possible adaptation to plant-based diets, via parental nutrition, should be explored. First, the maternal HC/LP nutrition induced a global DNA hypomethylation in the liver of their offspring. Interestingly at the gene expression level, the effects brought by the maternal and paternal HC/LP nutrition cumulated in the liver, as indi-cated by the altered transcriptome. The paternal HC/LP nutrition significantly enhanced cholesterol syn-thesis at the transcriptomic level. Furthermore, hepatic genes involved in long-chain polyunsaturated fatty acids were significantly increased by the parental HC/LP nutrition, affecting thus both hepatic and muscle fatty acid profiles. Overall, the present study demonstrated that lipid metabolism could be modulated via a parental nutrition in rainbow trout, and that such modulations have consequences on their progeny phenotypes. (c) 2022 The Author(s). Published by Elsevier B.V. on behalf of The Animal Consortium. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
