Research
| Name： | XIE Haixia |
|---|---|
| Academic Title： | Professor |
| Education： | Ph.D. |
| Phone： | 86-27-68780006 |
| E-mail： | xieh@ihb.ac.cn |
Resume：
Education
Ph.D., Institute of Hydrobiology, Chinese Academy of Sciences, Hydrobiology, 2005.
B.A., HuaZhong Agricultural University, Aquaculture, 1999.
Research Experience:
2019- Professor, Institute of Hydrobiology, the Chinese Academy of Sciences
2011-2018 Associate Professor, Institute of Hydrobiology, the Chinese Academy of Sciences
2017-2018 Visiting scholar, Imperial College, London.
2008-2010 Assistant Professor, Institute of Hydrobiology, the Chinese Academy of Sciences
2005-2008 PostDoc, Department of Biology, National University of Singapore
Research interests
Type III secretion system, biofilm, regulation, type I fimbriae, host-pathogen interaction, live attenuated vaccines
Research Grants as Principal Investigator
1. National Natural Science Foundation of China-Hainan Joint Fund (grant No.U23A20254, ￥3,300,000, 01/2024-12/2027): Invasion, immune evasion and immuno-prevention of Streptococcus agalactiae in tilapia.
2. National Natural Science Foundation of China (grant No.32073018, ￥690,000, 01/2021-12/2024): Molecular mechanism of Edwardsiella piscicida EseJ for its negative regulation of type I fmbria and inhibition of apoptosis.
3. National Natural Science Foundation of China (grant No.31572659, ￥763,200, 01/2016-12/2019): Type III translocon contributes to biofilm formation and virulence of Edwardsiella piscidida.
4. National Natural Science Foundation of China (grant No. 31172442, ￥560,000, 1/2012-12/2015): Pathogenic mechanism of the native pEI1 and pEI2 from Edwardsiella ictaluri.
5. National Natural Science Foundation of China (grant No. 30972278, ￥300,000, 1/2010-12/2012): Pathogenic mechanism of Type III and type VI secretion system in Edwardsiella ictaluri.
Selected Publications：
1. ZhiXiong Zeng, LuYi Liu, ShuiBing Xiao, JinFang Lu, YingLi Liu, Jing Li, YuanZe Zhou, LiJing Liao, DuanYou Li, Ying Zhou, Pin Nie, HaiXia Xie*. Secreted in a Type III Secretion System-Dependent Manner, EsaH and EscE Are the Cochaperones of the T3SS Needle Protein EsaG of Edwardsiella piscicida. mBio, 2022, 21:e0125022.
2. XiaoJian Liao, TianTian He, LuYi Liu, XiuLong Jiang, ShanShan Sun, YuHang Deng, LiQiang Zhang, HaiXia Xie*, Pin Nie*. Unraveling and characterization of novel T3SS effectors in Edwardsiella piscicida. mSphere, 2023, 8:e0034623.
3. DuanYou Li, YingLi Liu, XiaoJian Liao, TianTian He, ShanShan Sun, Pin Nie, HaiXia Xie*. Identification and Characterization of EvpQ, a Novel T6SS Effector Encoded on a Mobile Genetic Element in Edwardsiella piscicida. Frontiers in Microbiology, 2021, 12:643498.
4. TianTian He, Ying Zhou, YingLi Liu, DuanYou Li, Pin Nie, AiHua Li*, HaiXia Xie*. Edwardsiella piscicida type III protein EseJ suppresses apoptosis through down regulating type I fimbriae, which stimulate the cleavage of caspase-8. Cellular Microbiology, 2020, 22:e13193.
5. Qian Zhang, TianTian He, DuanYou Li , Pin Nie*, HaiXia Xie*. The Edwardsiella piscicida type III effector EseJ suppresses expression of type 1 fimbriae, leading to decreased bacterial adherence to host cells. Infection & Immunity, 2019, 87: e00187-19.
6. YingLi Liu, TianTian He, LuYi Liu, Jia Yi, Pin Nie, HongBing Yu, HaiXia Xie*. The Edwardsiella piscicida type III translocon protein EseC inhibits biofilm formation by sequestering EseE. Applied and Environmental Microbiology, 2019, 85:e02133-18.
7. LuYi Liu, Pin Nie*, HongBing Yu , HaiXia Xie*. Regulation of type III secretion of translocon and effector proteins by the EsaB/EsaL/EsaM complex in Edwardsiella tarda. Infection & Immunity, 2017, 85:e00322-17.
8. Jia Yi , ShuiBing Xiao, ZhiXiong Zeng, JinFang Lu, LuYi Liu, Zubair Ahmed Laghari, Pin Nie, HongBing Yu, HaiXia Xie*. EseE of Edwardsiella tarda augments the secretion of translocon protein EseC and the expression of escC-eseE operon. Infection & Immunity, 2016, 84:2336-2344.
9. JinFang Lu, WeiNa Wang, GaiLing Wang, HeZhang, YingZhou, ZhiPeng Gao, Pin Nie*, HaiXia Xie*. Edwardsiella tarda EscE (Orf13 protein) is a type III secretion system secreted protein that is required for the injection of effectors, secretion of translocators, and pathogenesis in fish. Infection & Immunity, 2016, 84:2-10.
10. ZhiPeng Gao, Pin Nie, JinFang Lu, LuYi Liu, TiaoYi Xiao, Wei Liu, JiaShou Liu*, HaiXia Xie*. Type III secretion system translocon component EseB forms filaments and mediates autoaggregation and biofilm formation in Edwardsiella tarda. Applied and Environmental Microbiology, 2015, 81:6078-6087.
11. HaiXia Xie, JinFang Lu, Ying Zhou, Jia Yi, Xiu-Jun Yu*, KaYing Leung, Pin Nie*. Identification and functional characterization of the novel Edwardsiella tarda effector EseJ. Infection & Immunity, 2015, 83:1650-1660.
12. HaiXia Xie, JinFang Lu, Nathalie Rolhion, David W. Holden, Pin Nie*, Ying Zhou, Xiu-Jun Yu*. Edwardsiella tarda-induced cytotoxicity depends on its type III secretion system and flagellin. Infection & Immunity, 2014, 82:3436-3445.
13. HaiXia Xie, HongBing Yu, Jun Zheng, Leonard J. Foster, Yu-Keung Mok, Brett B. Finlay, Pin Nie, KaYin Leung*. EseG, an effector of the type III secretion system of Edwardsiella tarda triggers microtubule destabilization. Infection & Immunity 2010, 78:5011-5021
